Synthesis, cytotoxic, anticancer and antimicrobial activities of some metal complexes of a novel tetradentate Schiff base ligand, (E)-3-((2-((E)-(1-(2-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-phenylbutanamide

Kumar, K. Subin; Aravindakshan, K. K.

doi:10.1016/j.rechem.2021.100129

Cited by 14 publications

(4 citation statements)

References 37 publications

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“…Te efective magnetic moments were calculated to be diamagnetic for Zn(II) complex [36,37]. Te efective magnetic moments measured experimentally were 2.03 BM corresponding to one unpaired electron supporting the distorted square-planar geometry for Cu(II) complex [37,38]; 4.34 BM relative to the presence of three unpaired electrons in the octahedral structure for Co(II) complex [33,37]; 5.85 BM indicated the octahedral geometry for Mn(II) complex [37,39]; and 6.08 BM due to the presence of fve unpaired electrons attributed the octahedral structure for Fe(III) complex [37,40] probably.…”

Section: Resultsmentioning

confidence: 87%

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Nguyen

Thi

Bui

et al. 2023

Heteroatom Chemistry

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An unsymmetrical salen-type Schiff base ligand, (Z)-1-(((2-((E)-(2-hydroxy-6-methoxybenzylidene)amino)phenyl)amino)methylene)naphthalen-2(1H)-one, and its Zn(II), Cu(II), Co(II), Mn(II), and Fe(III) complexes were synthesized and characterized by mass (MS), nuclear magnetic resonance (NMR), infrared (IR), ultraviolet-visible (UV-Vis) spectra, and effective magnetic moments. The thermal analyses of the obtained ligand and metal complexes were conducted by thermogravimetric analysis (TGA). Antimicrobial activity of the unsymmetrical Schiff base ligand and its metal complexes were examined for Staphylococcus aureus as Gram-positive bacteria and Escherichia coli as Gram-negative bacteria. In vitro anticancer property of synthetic compounds was estimated against human cancer cell lines, a subline of Hela tumor cell line (KB), and a human liver cancer cell line (HepG-2) as well.

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Section: Resultsmentioning

confidence: 87%

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Nguyen

Thi

Bui

et al. 2023

Heteroatom Chemistry

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“…1 H and 13 C NMR measurements were performed on an Advance-II 400 Bruker NMR spectrometer, SAIF, Chandigarh. Chemical shifts were determined using TMS as the internal standard and DMSO-d 6 as solvent. Infrared spectra of solids were recorded in the range 4000-400 cm −1 on a Nicolet Impact 400D Fourier transform infrared spectrophotometer using KBr pellets.…”

Section: General Procedures For the Preparation Of Dicumarol Derivati...mentioning

confidence: 99%

“…Enrofloxacin (EN) is an antibiotic that is very effective in the treatment of bacterial infections (6,7) . It can be taken by the oral or by injection into a vein; it is effective for pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and other types of infectious diarrhea.…”

Section: Introductionmentioning

confidence: 99%

Preparation, Structures and Antimicrobial Activity of Ni(II) Complexes on the Base of Enrofloxacin with Dicumarol Derivative

Prajapati¹,

Chaturvedi²

2023

IJST

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Objective: To synthesize Ni(II) complexes on the base of enrofloxacin with dicumarol derivative and to investigate their antioxidant and antimicrobial potentials. Methods: Ni(II) complexes have been synthesized by classical thermal methods by mixing aqueous metal solutions with ethanol ligands and enrofloxacin in a 1:1 molar ratio. A biologically strong ligand was prepared by refluxing a dicoumarol derivative in aldehyde and ethanol. The structures of the ligands and their nickel complexes were investigated and confirmed by elemental analysis, FT-IR, 1 H-NMR, 13 C-NMR and mass spectroscopy. The thermal behavior of newly synthesized mixed-ligand Ni(II) complexes was studied by thermogravimetric analysis. Ferric-reducing antioxidant power (FRAP) (antioxidant activity) of all complexes were measured. All the compounds were screened for their antimicrobial activity against E. coli; P. aeruginosa; S. pyogenes; C. albicans and A. niger using Luria Broth dilution method for MIC values. Both the ligand and its complex were screened for antioxidant and antimicrobial activity in vitro. Findings: Antioxidant and antimicrobial activities of complexes were found to be better than the parent ligands used for complex formation. MIC values for complex C 5 (-CH 3 derivative) were found to be between 40-70 µg/mL and FRAP values was 82.44 mmol/100g, indicative of its ferric reducing antioxidant power. These result show that complex C 5 (-CH 3 derivative) was found more potential as antimicrobial and antioxidant agent. Novelty : The coordination of metal complex with enrofloxacin (antibiotic) draws a scheme for the synthesis of new drug as well as increasing the activity of enrofloxacin that is currently in use. Current work supports that the activity of antibiotics could be increased by coordination of metal ion complex. There could be a possibility that these complexes allow to reduce the dose of drug introduced into the body.

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“…Schiff bases and their metallic complexes are compounds with a wide range of applications in the food and dye industry, analytical chemistry, catalysis, and agrochemicals [ 1 , 2 ]. Furthermore, these compounds have been shown to possess important biological activities such as anti-inflammatory, antibacterial, antifungal, antiparasitic, antiproliferative, and antiviral (including anti-HIV and anti-covid) properties [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Mononuclear and Tetranuclear Copper(II) Complexes Bearing Amino Acid Schiff Base Ligands: Structural Characterization and Catalytic Applications

et al. 2021

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Two new glycine-Schiff base copper(II) complexes were synthesized. Single crystal X-ray diffraction (SCXRD) allowed us to establish the structure of both complexes in the solid state. The glycine-Schiff base copper(II) complex derived from 2′-hydroxy-5′-nitroacetophenone showed a mononuclear hydrated structure, in which the Schiff base acted as a tridentate ligand, and the glycine-Schiff base copper(II) complex derived from 2′-hydroxy-5′-methylacetophenone showed a less common tetranuclear anhydrous metallocyclic structure, in which the Schiff base acted as a tetradentate ligand. In both compounds, copper(II) had a tetracoordinated square planar geometry. The results of vibrational, electronic, and paramagnetic spectroscopies, as well as thermal analysis, were consistent with the crystal structures. Both complexes were evaluated as catalysts in the olefin cyclopropanation by carbene transference, and both led to very high diastereoselectivity (greater than 98%).

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Synthesis, cytotoxic, anticancer and antimicrobial activities of some metal complexes of a novel tetradentate Schiff base ligand, (E)-3-((2-((E)-(1-(2-hydroxyphenyl)ethylidene)amino)ethyl)imino)-N-phenylbutanamide

Cited by 14 publications

References 37 publications

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Synthesis, Spectral Characterization, and Biological Activities of Some Metal Complexes Bearing an Unsymmetrical Salen-Type Ligand, (Z)-1-(((2-((E)-(2-Hydroxy-6-methoxybenzylidene)amino)phenyl)amino) methylene) Naphthalen-2(1H)-one

Preparation, Structures and Antimicrobial Activity of Ni(II) Complexes on the Base of Enrofloxacin with Dicumarol Derivative

Mononuclear and Tetranuclear Copper(II) Complexes Bearing Amino Acid Schiff Base Ligands: Structural Characterization and Catalytic Applications

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