Synthesis, cytotoxicity and DNA binding of novel Ni(II), Co(II) and Zn(II) complexes bearing pyrimidinyl hydrazone ligand

Yuan, Juan; Song, Junying; Yang, Heying; Lan, Hairong; Xing, Ai-Ping; Li, Kai-Hao; Zeng, Dai; Zhang, Zhenqiang; Feng, Shi Ting

doi:10.1016/j.molstruc.2022.134724

“…For instance, NSAIDs such as naproxen, ibuprofen, and mefenamic acid have exhibited synergistic anti-proliferative and anti-cancer effects [141]. In particular, zinc with DNA ligands has always demonstrated remarkable anti-inflammatory properties [142]. For instance, zinc (II) compounded with a 1,10-phenanthroline-5,6-dione ligand had similar anti-tumour activity to copper (II) compounded with a phenanthroline-phenazine ligand, as stated previously.…”

Section: Cuzn In Planar Aromatic Structuresmentioning

confidence: 65%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi¹,

Miskon²

2023

Preprint

0

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Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

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“…47 Zn( ii ) & Cd( ii ) complexes have revealed a strong ability to bind and cleave DNA via covalent and non-covalent interactions. 22,23 In the present study, UV-Visible spectroscopy, viscosity measurements and cyclic voltammetry were used to investigate the interactions of the synthesized compounds with CT-DNA through titration experiments, which indicated an interaction with the biopolymer.…”

Section: Resultsmentioning

confidence: 99%

“…The binding constant of all compounds can be found using the Benesi–Hildebrand equation (eqn (1))The intrinsic binding constant ( k b ) can be computed by the slope to intercept ratio. 22…”

Section: Methodsmentioning

confidence: 99%

“…20 Zinc derivatives could not be disregarded in the quest for anticancer metal-based therapies and are contemplated to be essential for the proper functioning of human metabolism and physiology due to its abundance, lower toxicity and ability to support different coordination geometries. 21,22 A number of Zn( ii ) and Cd( ii ) pincer complexes have been reported for promising anticancer activities against a variety of cancer cell lines. 17,23–26…”

Section: Introductionmentioning

confidence: 99%

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Zn(ii) and Cd(ii) pincer complexes bearing meta alkylated pyridinium amidates; synthesis & preliminary anticancer studies

Masood,

Babar,

Chaudhry

et al. 2023

New J. Chem.

9

0

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“…For instance, NSAIDs such as naproxen, ibuprofen, and mefenamic acid have exhibited synergistic anti-proliferative and anti-cancer effects [ 142 ]. In particular, zinc with DNA ligands has always demonstrated remarkable anti-inflammatory properties [ 143 ]. For instance, zinc(II) compounded with a 1,10-phenanthroline-5,6-dione ligand had similar anti-tumour activity to copper(II) compounded with a phenanthroline–phenazine ligand, as stated previously.…”

Section: Copper Zinc and Cuzn In Organic Solvent Formation Structuresmentioning

confidence: 99%

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zaidi

¹

,

Miskon

²

2023

Molecules

17

0

View full text Add to dashboard Cite

Due to its built-up chemoresistance after prolonged usage, the demand for replacing platinum in metal-based drugs (MBD) is rising. The first MBD approved by the FDA for cancer therapy was cisplatin in 1978. Even after nearly four and a half decades of trials, there has been no significant improvement in osteosarcoma (OS) therapy. In fact, many MBD have been developed, but the chemoresistance problem raised by platinum remains unresolved. This motivates us to elucidate the possibilities of the copper and zinc (CuZn) combination to replace platinum in MBD. Thus, the anti-chemoresistance properties of CuZn and their physiological functions for OS therapy are highlighted. Herein, we summarise their chelators, main organic solvents, and ligand functions in their structures that are involved in anti-chemoresistance properties. Through this review, it is rational to discuss their ligands’ roles as biosensors in drug delivery systems. Hereafter, an in-depth understanding of their redox and photoactive function relationships is provided. The disadvantage is that the other functions of biosensors cannot be elaborated on here. As a result, this review is being developed, which is expected to intensify OS drugs with higher cure rates. Nonetheless, this advancement intends to solve the major chemoresistance obstacle towards clinical efficacy.

show abstract

Synthesis, cytotoxicity and DNA binding of novel Ni(II), Co(II) and Zn(II) complexes bearing pyrimidinyl hydrazone ligand

Cited by 13 publications

References 105 publications

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

Zn(ii) and Cd(ii) pincer complexes bearing meta alkylated pyridinium amidates; synthesis & preliminary anticancer studies

Combining Copper and Zinc into a Biosensor for Anti-Chemoresistance and Achieving Osteosarcoma Therapeutic Efficacy

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