Synthesis, GC selective DNA binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one

Gao, Feng; Chao, Hui; Zhou, Feng; Chen, Xin; Wei, Yuanfang; Ji, Liang‐Nian

doi:10.1016/j.jinorgbio.2007.12.025

Cited by 76 publications

(36 citation statements)

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“…In some cases, Ru II polypyridyl complexes were found to photocleave DNA by sensitization of singlet oxygen ( 1 O 2 ) [15]. In others, 1 O 2 and superoxide anion radical (O .À 2 ) may play an important role in the photocleavage [9] [10] [30]. On the other hand, Ru complexes as antitumor drugs have attracted great attention; complex [H 2 im] [trans-RuCl 4 (dmso-S)(Him)] (NAMI-A; Him ¼ 1H-imidazole, dmso ¼ dimethyl sulfoxide) has entered clinical trials due to its very good antimetastatic activity [31] [32].…”

Section: (Dppz)]mentioning

confidence: 99%

“…[ [30]. When circular plasmid DNA is subjected to electrophoresis, relatively fast migration will be observed for the intact supercoil form (Form I); if scission occurs on one strand (nicking), the supercoil will relax to generate a slower-moving open circular form (Form II); if both strands are cleaved, a linear form (Form III) that migrates between Form I and Form II will be generated [48].…”

Section: (Dppz)]mentioning

confidence: 99%

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Synthesis, Structure, DNA‐Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

Liu¹,

Zeng²,

Jiang³

et al. 2010

Chemistry & Biodiversity

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Many ruthenium(II) complexes show high antitumor activities, and the in vitro antitumor activities are usually related to DNA binding. We designed and synthesized two Ru(II) polypyridyl complexes, [Ru(dmp)2(fpp)]2+ (dmp=2,9-dimethyl-1,10-phenanthroline; fpp=2-[3,4-(difluoromethylenedioxy)phenyl]imidazo[4,5-f] [1,10]phenanthroline and [Ru(phen)(2)(fpp)]2+ (phen=1,10-phenanthroline). The DNA-binding properties of these complexes have been investigated by spectroscopic titration, DNA melting experiments, viscosity measurements, and photoactivated cleavage. The mechanism studies of photocleavage revealed that singlet oxygen (1O2) and superoxide anion radical (O2(.-)) may play an important role in the photocleavage. The cytotoxicity of complexes 1 and 2 have been evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) method; complex 2 shows slightly higher anticancer potency than 1 does against all the cell lines screened.

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Section: (Dppz)]mentioning

confidence: 99%

Section: (Dppz)]mentioning

confidence: 99%

Synthesis, Structure, DNA‐Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

Liu¹,

Zeng²,

Jiang³

et al. 2010

Chemistry & Biodiversity

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“…2) showed a strong decrease in intensity (hypochromicity: 20.6% for complex 1 and 28.5% for complex 2) and a small red shift (3 nm for complex 1 and 2, respectively). The change in the absorbance of the MLCT band with increasing amounts of CT-DNA was used to derive the intrinsic [37], but smaller than the classical intercalators whose binding constants were in the order of 10 7 [38]. The different DNA-binding properties of complexes 1 and 2 are due to the different ancillary ligand.…”

Section: Absorption Titrationmentioning

confidence: 99%

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

Liu

Zeng

2009

Transition Met Chem

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The binding of the ruthenium(II) complexes [Ru(bpy) 2 (ITAP)](ClO 4 ) 2 (bpy = 2,2'-bipyridine) and [Ru(phen) 2 (ITAP)](ClO 4 ) 2 (phen = 1,10-phenanthroline, ,4,8,9-tetraazatriphenylene) to calf thymus DNA (CT-DNA) have been investigated with UVvisible and emission spectroscopy, viscosity measurements, thermal denaturation, and photoactivated cleavage. The experimental results indicate that the two complexes bind to CT-DNA through an intercalative mode. The two Ru(II) complexes in the presence of plasmid pBR322 DNA have been found to give rise to nicking of DNA upon irradiation.

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“…Therefore, development of GC-targeting probes is essential for the locating and reparation of DNA damage. To design novel, sensitive DNA molecular luminescent probes for GC sequences, we have prepared a guanine-functionalized, dppz-based Ru II -complex [Ru(bpy) 2 2 þ with calf-thymus (CT) DNA, poly(dA) · poly(dT), and poly(dG) · poly(dC) was studied [73]. Viscosity measurements and DNA thermal denaturation experiments suggest that, upon modification of dppz ligand, [Ru(bpy) 2 (appo)] 2 þ preserves the high DNA-binding affinity of its parent complex [Ru(bpy) 2 (dppz)] 2 þ , and binds CT-DNA, poly(dA) · poly(dT), and poly(dG) · poly-(dC) in an intercalative mode.…”

Section: -A : 2'3'-c]phenazine) Led To the Complex [Ru(tpm)(py)(dppn)]mentioning

confidence: 99%

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

Gao

Chao

2008

Chemistry & Biodiversity

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The interaction of ruthenium(II)-polypyridyl complexes with DNA has attracted considerable interests during the past two decades. This paper presents some recent progresses in our laboratory on the interaction of Ru(II)-polypyridyl complexes with DNA. The first part describes the effect of modulating the intercalative ligand on the DNA-binding behaviors of the complexes, such as DNA-binding affinity, DNA-binding enantioselectivity, DNA molecular 'light switch' effect, and DNA sequence selectivity. The second part focuses on the DNA photocleavage by the complexes and its mechanism. In the final part, we discuss the topoisomerase inhibition and its mechanism, as well as the antitumor activity of the Ru(II)-polypyridyl complexes.

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Synthesis, GC selective DNA binding and topoisomerase II inhibition activities of ruthenium(II) polypyridyl complex containing 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one

Cited by 76 publications

References 64 publications

Synthesis, Structure, DNA‐Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

Synthesis, Structure, DNA‐Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

Synthesis and DNA interaction studies of ruthenium(II) complexes with isatino[1, 2-b]-1,4,8,9-tetraazatriphenylene as an intercalative ligand

DNA Binding, Photocleavage, and Topoisomerase Inhibition of Functionalized Ruthenium(II)‐Polypyridine Complexes

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