Synthesis, identification, and cytotoxicity effect of Oxazapine scaffolding

Abstract

The research includes the preparation of two Schiff bases MA (2-1) and some of their derivatives from the reaction of para-bromobenzaldehyde or para-methoxy benzaldehyde with stoichiometric 5-methyl pyrazole-3-amino in the presence of glacial acetic acid. Then the corresponding oxazepine rings MA (6-3) were prepared from each MA (2-1) with maleic anhydride or phthalic anhydride. The prepared chemical formulas were spectroscopically confirmed using FTIR and 1HNMR spectroscopy. The biological activity of MA5 had tested against MDA breast cancer and REF healthy cells at seven concentrations (500,250,125,62.5,31.5,15.5,7.5) µg / ml. The compound showed a high inhibition against cancer cells, so this makes it a candidate as a drug for future cytotoxicity.