Synthesis, Identification, Theoretical Study and effect of 1,3,4-Oxadiazole Compounds Substituted on Creatinine ring on the activity of some Transfers Enzymes

Khudhair, Zahraa T.; Al-Tamimi, Entesar O.

doi:10.5958/0974-360x.2019.00611.5

Cited by 4 publications

(3 citation statements)

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“…Uncorrected melting points were recorded with a Gallen Kamp capillary melting point apparatus, and FT-IR measurements taken with a SHIMADZU model FTIR-8400S. 1 H-NMR spectra were recorded in DMSO solution with TMS as an internal standard using a Bruker spectrophotometer model ultra-shield at 400 MHz. [10] In round-bottomed flask creatinine (0.01 mol, 1.13 g), (0.01 mol, 1 mL) ethyl chloroacetate, and potassium carbonate (0.015 mol, 2.07 g) in 1,4-dioxane (20 mL) were refluxed at 70 °C for 24 hours.…”

Section: Methodsmentioning

confidence: 99%

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Untitled

2023

J. Med. Chem. Sci.

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The synthesis of many new 2-substituted 1,3,4-oxadiazoles from creatinine is studied in this research. The ester of creatinine 1a was formed by the reaction of creatinine with ethylchloroacetate, and then with two of alkyl halides to produce compounds 2a-2b. Following that, hydrazide derivatives 3a-3b were produced by compounds 2a-2b with semicarbazide hydrochloride. These hydrazides were cyclized with 5 percent sodium hydroxide to produce 1,3,4oxadiazole derivatives 4a-4b. The reaction of these compounds with aromatic aldehydes produced Schiff bases 5a-5d. Finally, diazetidine 6a-6h and βlactam 7a-7d derivatives on position (2) from 1,3,4-oxadiazole were formed by reacting Schiff bases with various reagents. FT-IR spectroscopy and 1 H-NMR for some synthesized compounds were used to identify the newly synthesized compounds. In vitro, antioxidant activities of some synthesized compounds were also investigated with promising results.

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Section: Methodsmentioning

confidence: 99%

“…Creatinine is generated when creatine is broken down in the body, and then passed through the kidneys [1]. A creatinine serum test can be used to determine the amount of creatinine in the blood.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Different substrate concentrations of these enzymes SGOT and SGPT were produced using buffers [(phosphate buffer pH = 7.40, 100 mmol/L)]. The enzyme velocity was estimated using the Burke and Linweaver equation and plotting 1/v versus 1/[s] were evaluated values; Ka, apparent Vmax (Vmapp), apparent Km (Kmapp), kind of inhibition or activation 18,19 .…”

Section: A Constant Concentration Of Compounds (B3 and B5) (10 -2 M)mentioning

confidence: 99%

Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes

et al. 2022

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The target of this study was to synthesize several new Ciprofloxacin drug analogs by providing a nucleophilic substitution procedure that provides new functionality at the carboxylic group location. The analogs were synthesized, designed, and characterized by 1HNMR, and FTIR. The synthetic path began from the reaction of ciprofloxacin drug with morpholine to give compound[B], ciprofloxacin derivative was linked with a variety of primary and secondary amines to give compounds[B1-B9]. The above-mentioned prepared compounds [B3 and B5] were applied to liver enzymes, and the increase in the activity of these enzymes was observed. In addition, a theoretical study was conducted to study the energies and properties of the prepared compounds.

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Synthesis of 1,3-Benzoxazepine-1,5-diones containing Oxadiazole unit with Assessment of their verves Athwart Bacteria

Abood

Suhail

Chafcheer

2021

RJPT

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Treatment of 4-aminobenzoyl hydrazide (1) with (CS2) and potassium hydroxide in absolute (EtOH) resulted in formation of 5-(4-aminophenyl)-2-thiol-1,3,4-oxadiazole (2). Compound (2) has been converted to the diazonium salt which reacted with 2-hydroxybenzaldehyde for producing the aldehyde derivative (3). Reaction of compound (3) with (4-nitroaniline, 3-nitroaniline, 2-nitroaniline, 4-chloroaniline, 2-chloroaniline, 2,4-dichloroaniline and 4-bromoaniline) by (MW) method in (EtOH) afforded seven Schiff bases (4a–g). Cycloaddition of imines (4a–g) with phthalic anhydride in microwave oven gave seven 1,3-benzoxazepine-1,5-diones (5a–g) bearing oxadiazole moiety. Screening verves of final benzoxazepines was done on Staphylococcus aurous and Escherichia coli. The implications explained that compounds (5b, 5c, 5d, 5e, 5f and 5g) possess higher effect than gentamycin against Staphylococcus aurous. Moreover, the 1,3-oxazepine-1,5-diones (compounds 5a, 5b, 5c, 5d, and 5g) appeared better action against Escherichia coli comparably with the standard antibiotic.

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Synthesis, Identification, Theoretical Study and effect of 1,3,4-Oxadiazole Compounds Substituted on Creatinine ring on the activity of some Transfers Enzymes

Cited by 4 publications

References 0 publications

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Untitled

Synthesis, Identification, Theoretical Study, and Effect of the New Heterocyclic System from Ciprofloxacin Derivatives on the Activity of Some Liver Enzymes

Synthesis of 1,3-Benzoxazepine-1,5-diones containing Oxadiazole unit with Assessment of their verves Athwart Bacteria

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