Synthesis, Isomerization, and Antimicrobial Evaluation of Some Pyrazolopyranotriazolopyrimidine Derivatives.

Abstract

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Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole

“…DMF alone was used as control at the same aforementioned concentration and, therefore, showed no visible change in bacterial growth. The plates were incubated at 37 C for 24 h for bacteria and for 48 h at 25 C for fungi. The mean zone of inhibition is measured in mm ± standard deviation beyond well diameter (6 mm).…”

“…The mean zone of inhibition is measured in mm ± standard deviation beyond well diameter (6 mm). Compounds that showed growth IZs (412 mm) were further evaluated for their MICs using the twofold serial dilution technique 25 .…”

“…Then, 10 mL of the broth containing about 10 6 CFU/mL of test bacteria or 10 4 CFU/mL of the test fungus was added to each well of 96-well microtiter plate. The sealed microplates were incubated at 37 C for 24 h for antibacterial activity and at 25 C for 48 h for antifungal activity in a humid chamber. At the end of the incubation period, the MICs values were recorded as the lowest concentrations of the substance that had no visible turbidity.…”

Synthesis and Biological Evaluation of some Novel Pyrano[2,3-<i>d</i>]Pyrimidine Derivatives

“…If pyrano [2,3-d]pyrimidine moieties are clubbed into one molecule, then resultant derivative enhances its pharmaceutical activity as abundant in biologically active compounds such as antitumour [5], cardiotonic [6], antibronchitic [7] and antifungal activity [8]. Some of them exhibit antihypertensive activity [9], antimalarial [10], analgesic [10,11], and antimicrobial and antiviral evaluation [12,13] properties. Pyrano [2,3-d]pyrimidines are building blocks used to evaluate their antimicrobial activities and various derived natural products [14].…”

Synthesis, Biological Evaluation of Some 2,3-dihydropyrazoles and Thiazoles as Anti-inflammatory and Antibacterial Agents

“…Pyrazole moiety makes the core structure of various drugs such as difenamizole (Kameyama et al [13,14] celecoxib [15] tepoxalin [16] etc. Besides this, there are several reports in the literature on the antiinflammatory [17][18][19][20] and antimicrobial properties [21][22][23] of pyrazoles. However studies investigating the potential of pyrazole derivatives as dual antimicrobial-anti-inflammatory agents have only recently been initiated [24][25][26][27].…”