Synthesis, modification and bioapplications of nanoscale copper chalcogenides

Yun, Baofeng; Zhu, Hongqin; Yuan, Jiaxin; Sun, Qiao; Li, Zhen

doi:10.1039/d0tb00182a

Cited by 51 publications

(50 citation statements)

References 302 publications

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“…Transition Metal Dichalcogenides (TMDCs), denoted as MX 2 , are composed of transition metals; M denotes a group 4–7 element (such as Mo, W, Ta, Nb, and Mn), and X denotes chalcogens (such as S and Se) ( Yun et al, 2020 ). The different structural compositions of TMDCs give them different properties, such as metals (NbS 2 , VSe 2 ), semiconductors (MoS 2 , WS 2 ), insulators (HfS), semi-metals (WTe 2 , TiSe 2 ), and even superconductors (NbSe 2 , TaS 2 ) ( Zhang et al, 2018 ), for applications in different biological fields.…”

Section: Transition-metal Based Nanomaterials and Their Propertiesmentioning

confidence: 99%

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

et al. 2022

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With the developments of nanobiotechnology and nanomedicine, non-invasive thermal ablation with fewer side effects than traditional tumor treatment methods has received extensive attention in tumor treatment. Non-invasive thermal ablation has the advantages of non-invasiveness and fewer side effects compared with traditional treatment methods. However, the clinical efficiency and biological safety are low, which limits their clinical application. Transition-metal based nanomaterials as contrast agents have aroused increasing interest due to its unique optical properties, low toxicity, and high potentials in tumor diagnosis. Transition-metal based nanomaterials have high conversion efficiency of converting light energy into heat energy, good near-infrared absorption characteristics, which also can targetedly deliver those loaded drugs to tumor tissue, thereby improving the therapeutic effect and reducing the damage to the surrounding normal tissues and organs. This article mainly reviews the synthesis of transition-metal based nanomaterials in recent years, and discussed their applications in tumor thermal ablation and diagnosis, hopefully guiding the development of new transition metal-based nanomaterials in enhancing thermal ablation.

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Section: Transition-metal Based Nanomaterials and Their Propertiesmentioning

confidence: 99%

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

et al. 2022

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“…InP/ZnS@ PLA-PEG micelles were further embellished with an anti-EGFR nanobody (7D12 Nbs) to assess the therapeutic effect of triple-negative breast tumor. As we know, CuS have been demonstrated as potent theranostic nanotool with promising outcomes in the past decade ( Yun et al, 2020 ; Dong et al, 2020 ). The cetuximab-modified CuS NPs (CuS-Ab NPs) were constructed as a synergistic anti-cancer agent, which could successfully suppress the tumor spread and growth ( Li et al, 2018 ).…”

Section: Non-metallic Nanoparticlesmentioning

confidence: 99%

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Sun

Wang

et al. 2021

Front. Pharmacol.

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Epidermal growth factor receptor (EGFR) is an anticancer drug target for a number of cancers, such as non-small cell lung cancer. However, unsatisfying treatment effects, terrible side-effects, and development of drug resistance are current insurmountable challenges of EGFR targeting treatments for cancers. With the advancement of nanotechnology, an increasing number of inorganic nanomaterials are applied in EGFR-mediated therapy to improve those limitations and further potentiate the efficacy of molecular targeted cancer therapy. Given their facile preparation, easy modification, and biosecurity, inorganic nanoparticles (iNPs) have been extensively explored in cancer treatments to date. This review presents an overview of the application of some typical metal nanoparticles and nonmetallic nanoparticles in EGFR-targeted therapy, then discusses and summarizes the relevant advantages. Moreover, we also highlight future perspectives regarding their remaining issues. We hope these discussions inspire future research on EGFR-targeted iNPs.

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“…[11,12,[25][26][27][28] Especially, it has been well demonstrated that copper selenide (Cu 2-x Se) nanoparticles (NPs) with intrinsic features for NIR-induced PA imaging, PTT, PDT, and also Fenton reaction-based chemodynamic therapy owing to the generation of ROS through the reaction of Cu + with endogenous H 2 O 2 within the tumor. [29][30][31][32][33][34][35][36][37] NIR-II light (1000-1700 nm) is featured with lower background signal, deeper penetration for tumor therapy, and higher permissible exposure to the skin compared with NIR-I laser with a wavelength of 650-950 nm. [38,39] Therefore, it is highly desirable to construct high-performance photothermal therapeutic agents for PTT in the NIR-II biowindow, especially for treating those deep-tissue-seated tumors like orthotopic bladder tumors.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated Chitosan Mediated Synthesis of Copper Selenide Nanoparticles with Enhanced Penetration for Second Near‐Infrared Photothermal Therapy of Bladder Cancer

Zhang

Deng

et al. 2021

Advanced Therapeutics

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The emergence of near-infrared-II (NIR-II) light activated photomedicines has extended the penetration depth for noninvasive theranostics, especially for photothermal nanomedicines. Intravesical instillation therapy of bladder cancer (BCa) is restricted greatly due to the short residence time and the low penetration ability of therapeutic agents in clinic. Therefore, improving the mucoadhesiveness and penetration of therapeutic agents are crucial factors in treatment of BCa. The development of NIR-II light triggered photothermal transduction agents for enhanced penetration and photothermal ablation of BCa post-intravesical instillation has not yet been investigated. Herein, Cu 2-x Se biocompatible particles are prepared through a fluorinated chitosan (FCS)mediated one-pot aqueous approach, which possesses enhanced penetrating ability and high photothermal conversion capability for effective NIR-II photothermal therapy (PTT). Owing to the outstanding transmucosal ability of FCS, FCS capped Cu 2-x Se nanoparticles exhibit much better transmucosal and penetration performance than their non-fluorinated counterparts to significantly improve the therapeutic efficacy of NIR-II PTT to ablate orthotopic bladder tumors. This study presents a promising phototherapy agent based on Cu 2-x Se modified with FCS for efficient NIR-II PTT for BCa treatment post-intravesical instillation.

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Synthesis, modification and bioapplications of nanoscale copper chalcogenides

Abstract: The recent advances in the synthesis, modification and bioapplications of nanoscale copper chalcogenides are comprehensively reviewed.

Cited by 51 publications

References 302 publications

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

Recent Advances in Transition-Metal Based Nanomaterials for Noninvasive Oncology Thermal Ablation and Imaging Diagnosis

The Application of Inorganic Nanoparticles in Molecular Targeted Cancer Therapy: EGFR Targeting

Fluorinated Chitosan Mediated Synthesis of Copper Selenide Nanoparticles with Enhanced Penetration for Second Near‐Infrared Photothermal Therapy of Bladder Cancer

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