Synthesis, molecular docking analysis and <i>in vitro</i> evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents

Nguyen, Ha Thanh; Van, Ket Tran; Pham-The, Hai; Braire, Julien; Thi, Phuong Hoang; Nguyen, Tuan Anh; Nguyen Thi, Quynh Giang; Dang Thi, Tuyet Anh; Le-Nhat-Thuy, Giang; Le Thi, Tu Anh; Ngoc, Doan Vu; Nguyen Van, Tuyen

doi:10.1039/d3ra07396c

RSC Adv.

2024

DOI: 10.1039/d3ra07396c

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Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents

Ha Thanh Nguyen,

Ket Tran Van,

Hai Pham-The

et al.

Abstract: Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents.

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Cited by 2 publications

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Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent

Liu,

Zhao,

Yin

et al. 2024

Chemistry & Biodiversity

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Pharmacological studies have shown that podophyllotoxin (PTOX) has anti‐tumor, antiviral and anti‐inflammatory effects. More and more derivatives of PTOX, such as VM‐26, NK‐611 and GL‐331, have gradually been synthesized and widely used in clinical practice. Sinopodophyllum hexandrum rhizome is rich in PTOX, which is much higher than other PTOX source plants. At present, research on S. hexandrum mainly focuses on artificial cultivation, chemical compositions, pharmaceutical value and the biosynthesis pathway of PTOX. However, the researches are relatively scattered and systematic review on PTOX is very limited. Therefore, this study performed a comprehensive investigation in terms of the plant origin source, content profile, and biological activities, in order to provide an integrated reference for in‐depth research and clinical application of PTOX in the chemistry and pharmacy fields, which can promote the innovative utilization of S. hexandrum resources and research and development of new anticancer drugs.

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Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent

Liu,

Zhao,

Yin

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds

Nguyen,

Pham-The,

Tuan

et al. 2024

Bioorganic & Medicinal Chemistry Letters

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Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents

Abstract: Synthesis, molecular docking analysis and in vitro evaluation of new heterocyclic hybrids of 4-aza-podophyllotoxin as potent cytotoxic agents.

Cited by 2 publications

References 68 publications

Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent

Plant Origin Source, Content Profile and Bioactivity of Podophyllotoxin as an Important Natural Anticancer Agent

Improved synthesis, molecular modeling and anti-inflammatory activity of new fluorinated dihydrofurano-naphthoquinone compounds

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