Synthesis, Molecular Spectroscopy, Computational, Thermal Analysis and Biological Activity of Some Orotic Acid Complexes

Masoud, Mamdouh S.; Ali, Alaa E.; Elfatah, Ashimaa S. Abd; Amer, Gomaa E.

doi:10.4236/ojinm.2021.111001

Cited by 3 publications

(2 citation statements)

References 46 publications

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“…Many previously reported studies (24) depending on proposing the fragmentation pathways of prepared ligand.. Mass spectrum of (HMABP), Figure (10), showed the mother ion peak at (m/z+=501.4), as parent ion peak which related to (M++H), this is consider good evidence to prepared the new ligand. The others fragment and their relative abundances and fragmentation pathways are shown in Table (5) and Scheme (4).…”

Section: Mass Spectrum For the Azo Ligand (Hmabp)mentioning

confidence: 80%

Synthesis, spectral properties and antibacterial studies of new hetrocyclic schiff-azo ligand derived from 5-amino 2-phenyl.4h-pyrazol-3-one with some transition metal complexes

Mohammed¹,

Wadday

2022

ijhs

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In this article, a synthesized ligand [5-amino 2-phenyl.4H-pyrazol-3-one ] and it was used to prepare new complexes of Mn (II),Co(II), Ni(II), Cu(II), Zn(II), Pd(II) and Ag(I). The new ligand (HMABP) has categorized by Micro Elemental Analysis (C.H.N.S), UV-visible, Fourier Transform infrared (FTIR) approaches, 1H,13C-NMR spectroscopy and mass spectroscopy. The consequence has specified that the ligand was represented as N,N,O-tetradentate. The preparing of complexes has accomplished after fixing the finest concentration and pH. UV-Vis spectra of these complexes solutions have been examined for a range of pH (3-10) and concentration (1x10-4-5.5x10-4) Molar that comply with Lambert-Beers Law. A stoichiometry of the complexes has comprehended in relation to mole ratio which has gotten from spectroscopic investigations of the complex has solutions. The ratio of metal: ligand was achieved with (1:1) for all complexes. The metal ions complexes were characterized by FTIR, UV-Visible, molar conductance, atomic absorption, magnetic susceptibility, elemental analysis C.H.N.S techniques. From the results of physico-chemical and spectral techniques, octahedral geometry except with Pd2+ was square planar and tetrahedral shape with Ag+ have been proposed for these metal complexes.

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Section: Mass Spectrum For the Azo Ligand (Hmabp)mentioning

confidence: 80%

Synthesis, spectral properties and antibacterial studies of new hetrocyclic schiff-azo ligand derived from 5-amino 2-phenyl.4h-pyrazol-3-one with some transition metal complexes

Mohammed¹,

Wadday

2022

ijhs

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“…= 5.1%; calcd. = 3.54%) [99,100]. In the temperature range of 141-260 • C, there is a decomposition of two benzoate moieties and one Hdmpz molecule (obs.…”

Section: Thermogravimetric Analysismentioning

confidence: 99%

Energetic Features of H-Bonded and π-Stacked Assemblies in Pyrazole-Based Coordination Compounds of Mn(II) and Cu(II): Experimental and Theoretical Studies

Boro,

Baishya,

Frontera

et al. 2024

Crystals

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Two new coordination compounds comprising Mn(II) and Cu(II) viz. [Mn(bz)2(Hdmpz)2(H2O)] (1) and [Cu(crot)2(Hdmpz)2] (2) (where, bz = benzoate; crot = crotonate; Hdmpz = 3, 5-dimethyl pyrazole) were synthesized and characterized. The characterization involved a single crystal X-ray diffraction technique, FT-IR spectroscopy, electronic spectroscopy, TGA, and elemental analyses. Compounds 1 and 2 crystallize as mononuclear entities of Hdmpz with penta-coordinated Mn(II) and hexa-coordinated Cu(II), respectively. These complexes exhibit distorted trigonal bipyramidal and distorted octahedral geometries, respectively. A crystal structure analysis of compound 1 elucidates the existence of C–H⋯π and π-stacking interactions alongside O–H⋯O, N–H⋯O, and C–H⋯O H-bonding interactions contributing to the stabilization of the compound’s layered assembly. Similarly, in compound 2, the crystal structure stability is attributed to the presence of hydrogen bonding in conjugation with π-stacking interactions. We conducted theoretical investigations to analyze π⋯π, H-bonding, and antiparallel CH···π non-covalent interactions observed in compounds 1 and 2. DFT calculations were performed to find out the strength of these interactions energetically. Moreover, QTAIM and non-covalent interaction (NCI) plot index theoretical tools were employed to characterize them and evaluate the contribution of the H-bonds.

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Recent trends in medicinal applications of mercury based organometallic and coordination compounds

Maqsood,

Al-Rawi,

Ibrahim

et al. 2024

Reviews in Inorganic Chemistry

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Metal-based drugs are finding new medical applications, particularly in antibacterial therapies. Compounds such as Prontosil and ciprofloxacin, as well as its derivatives such as beta-lactam drugs, aminoglycosides, vancomycin, fosfomycin, as well as tetracyclines, play critical roles in the prevention of bacterial and fungal infections. The increasing prevalence of microbial resistance is prompting the use of metal complexes to tackle fungal and bacterial strains. Mercury-based complexes, which are known for their unusual characteristics and reactivity, have received a lot of interest in the field of medicine recently. Additionally, Schiff base complexes are widely used as antifungal, antibacterial, and anticancer drugs, as well as in dye manufacturing. This article discusses current advances in the use of mercury compounds for combating fungus and bacteria, offering information on their efficacy and future applications.

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Synthesis, Molecular Spectroscopy, Computational, Thermal Analysis and Biological Activity of Some Orotic Acid Complexes

Cited by 3 publications

References 46 publications

Synthesis, spectral properties and antibacterial studies of new hetrocyclic schiff-azo ligand derived from 5-amino 2-phenyl.4h-pyrazol-3-one with some transition metal complexes

Synthesis, spectral properties and antibacterial studies of new hetrocyclic schiff-azo ligand derived from 5-amino 2-phenyl.4h-pyrazol-3-one with some transition metal complexes

Energetic Features of H-Bonded and π-Stacked Assemblies in Pyrazole-Based Coordination Compounds of Mn(II) and Cu(II): Experimental and Theoretical Studies

Recent trends in medicinal applications of mercury based organometallic and coordination compounds

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