Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

Mbah, James A.; Ayimele, Godfred A.; Eyonganyoh, Elvis N.; Nfor, Emmanuel N.

doi:10.4236/ijoc.2017.72007

Cited by 5 publications

(5 citation statements)

References 11 publications

(9 reference statements)

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“…The vanillin thiosemicarbazone and its cobalt(II), nickel(II), copper(II) and zinc(II) complexes were characterized through elemental analysis, molar conductivity, magnetic moment, electronic spectra, infrared spectra, 1 H, 13 C NMR spectra, thermogravimetric analysis, powder XRD analysis and SEM analysis. Based on the data, an octahedral geometry was assigned for the cobalt and nickel complex, square planar geometry for copper complex and a tetrahedral geometry for zinc complex.…”

Section: Discussionmentioning

confidence: 99%

“…10,11 Earlier reports show that their metal complexes, due to their ability to form stable chelates with essential metal ions, exhibit enhanced activity. [12][13][14][15] Certain thiosemicarbazones complexes were reported to have applications as nanoprecursor. 16,17 The present study reports the synthesis, characterization and biological activities of cobalt, nickel, copper and zinc complexes of vanillin-4-methyl-4-phenyl-3thiosemicarbazone.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Kumar¹,

Nath²

2019

J Chem Sci

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Complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone with cobalt(II), nickel((II), copper(II) and zinc(II) metal ions were synthesized and characterized by elemental analysis, molar conductance, magnetic moment, infrared spectra, electronic spectra, 1 H and 13 C NMR, mass spectrum and thermal analysis. The low molar conductance values indicate that all the complexes are non-electrolytes. Spectral studies indicate that the ligand act in a tridentate manner coordinating with the metal ion through sulphur, oxygen and nitrogen atoms. Based on magnetic moment measurements, spectral studies and thermal analysis, suitable geometry was proposed for the metal complexes. Thermal stability of the complexes was ascertained on the basis of thermo gravimetric analysis and the lattice parameters, space group and grain size of the ligand and complexes were determined by using powder XRD measurements. Surface morphology of ligand and complexes were studied using SEM analysis. Antimicrobial studies were carried out against gram-positive, gram-negative bacteria and two fungal pathogens.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Kumar¹,

Nath²

2019

J Chem Sci

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“…The presence of citral could always explain this activity. We insist on the fact that these noted bactericidal activities relate to the compounds obtained during this work, because thiosemicarbazone compounds according to the works of [36] have revealed very interesting bactericidal properties.…”

Section: Minimum Inhibitory Concentrations Of Substancesmentioning

confidence: 95%

“…Among hemi-synthesized molecules, only the synthesis of CThio had been reported in the literature from commercial citral [36]. To our knowledge, it was during this work that compounds CPthio had been synthesized for the first time by ours methods.…”

Section: Physical Properties Of Thiosemicarbazones Hemi-synthesized In C Citratus Essential Oilmentioning

confidence: 98%

Comparative antimicrobial activity of Cymbopogon citratus essential oil and thiosemicarbazones derived from this oil

Sakirigui¹,

Sika²,

Koffi³

et al. 2021

GSC Adv. Res. Rev.

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Introduction: The presence of microbes in our environment is always a permanent public health problem. In this context, research on natural treatment, less expensive and accessible to fight these microbial germs would be beneficial. Methods: During this work, molecules of thiosemicarbazones due to their numerous biological activities were hemi-synthesized in situ in the essential oil of Cymbopogon citratus in order to evaluate their antimicrobial activities. Results: Analysis of the essential oil extracted by hydrodistillation revealed the presence of 72.91% of citral. Citralthiosemicarbazone (CThio) and citral 4-phenyl-3-thiosemicarbazone (CPthio) were hemi-synthesized in this oil with interesting yields of 83% and 91%, respectively. After purification and confirmation of the structures of these molecules, the three substances were tested on eleven strains of microbes. Determination of the inhibition diameters showed that the activity of the essential oil is best in over 80% of strains. However, the largest diameter of inhibition (26 mm) was noted with CPthio against Salmonella typhi R 30951401. The determination of the minimum inhibitory concentrations showed that the oil remains more active with the smallest value of 0.3125 mg / ml against Micrococcus luteus. The lower value of minimum bactericidal concentrations was also obtained with the essential oil against Enterococcus foecalis ATCC 29212. Conclusion: The essential oil of C. citratus remains more active in the majority cases. It could be a great alternative in the fight against bacteria, and the advantage is that it remains a natural substance.

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“…Thiosemicarbazones are useful in the medicinal and pharmaceutical fields because of their great significant pharmacological properties such as antibacterial [2] [3] [4], antifungal [2], anti-HIV [5] [6] [7] anticancer [8] [9], antineoplastic [10], anti-inflammatory [11], tuberclostatic [12], antimalarial [13] [14] and their variable bonding nature. In continuation with our earlier work on heterocyclic thiosemicarbazone derivatives [15], the present paper reports on the synthesis and antibacterial studies of 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT).…”

Section: Introductionmentioning

confidence: 90%

Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone

Mbah¹,

Ayimele²,

Kodjio³

et al. 2017

IJOC

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A novel ligand, 1-(4-methoxybenzylidene)-4-methylthiosemicarbazone (MBT) derived from 4-methoxybenzaldehyde was synthesized and characterized by spectroscopic methods (IR, 1 H NMR, 13C NMR), single crystal X-ray diffraction technique and physical means. MBT showed antibacterial activity in vitro with MICs of 64 μg/mL (a strain of Salmonella typhi (ATCC 6539)), 128 μg/mL (Salmonella typhi), 64 μg/mL (Salmonella paratyphi A), 128 μg/mL (Salmonella paratyphi B) and 64 μg/mL (Salmonella typhimurium). The results showed that MBT demonstrated moderate in vitro antibacterial activity against a strain of Salmonella typhi (ATCC 6539), Salmonella paratyphi A, and Salmonella typhimurium, indicating its promise as a possible lead for the discovery of antibacterial drugs.

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Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

Cited by 5 publications

References 11 publications

Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Synthesis, characterization and biological studies of cobalt(II), nickel(II), copper(II) and zinc(II) complexes of vanillin-4-methyl-4-phenyl-3-thiosemicarbazone

Comparative antimicrobial activity of Cymbopogon citratus essential oil and thiosemicarbazones derived from this oil

Synthesis, Molecular Structure and Antibacterial Activity of 1-(4-Methoxybenzaldehyde)-4-Methylthiosemicarbazone

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