Synthesis, molecular structure, biological properties and molecular docking studies on MnII, CoII and ZnII complexes containing bipyridine–azide ligands

Thamilarasan, Vijayan; Jayamani, Arumugam; Sengottuvelan, Nallathambi

doi:10.1016/j.ejmech.2014.09.073

Cited by 66 publications

(17 citation statements)

References 72 publications

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“…In an earlier work we had studied the molecular structures and biological properties of cobalt, manganese and zinc complexes of bipyridine containing azides as co-ligands [20]. In this work we have studied the synthesis, crystal structures, spectral characterizations, DNA interaction, BSA binding and antimicrobial activities of mono/binuclear copper(II) bipyridine complexes with three different axial ligands (Cl, CH 3 COO, ClO 4 ).…”

Section: Introductionmentioning

confidence: 99%

Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

et al. 2015

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Section: Introductionmentioning

confidence: 99%

Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

et al. 2015

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“…The competitive binding of the complexes with EtBr was investigated with fluorescence spectroscopy in order to examine whether the compounds were able to displace EtBr from its FS‐DNA–EtBr complexes . EtBr emits intense fluorescence at about 600 nm in the presence of DNA due to the strong intercalation between the adjacent DNA base pairs .…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4‐bis (pyrazol‐1‐yl) terephthalic acid

Gao

Xing

et al. 2018

Applied Organom Chemis

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Two novel complexes, [Cu (L)(H2O)]⋅H2O (1) and [Mn (H2O)6] ⋅L ⋅H2O (2) (L = 1,4‐bis (pyrazol‐1‐yl) terephthalic acid), were synthesized under hydrothermal conditions. They were characterized using elemental analysis, infrared spectroscopy and single‐crystal X‐ray diffraction. Intramolecular weak interactions, such as hydrogen bonds, and intermolecular interactions play important roles in the construction of the complexes. The interaction of these complexes with fish sperm DNA (FS‐DNA) was monitored and binding constants were determined using UV–visible spectroscopy, which revealed their ability to bind to FS‐DNA, with binding constants for the two complexes of 1.88 × 104 M−1 (1) and 1.06 × 104 M−1 (2). Viscosity experiments further demonstrated the binding of the complexes to DNA. The complexes were further studied using gel electrophoresis assay with supercoiled plasmid pBR322 DNA. In addition, anticancer activities of the metal complexes investigated through MTT assays in vitro indicated good cytotoxic activity against cancer cell lines. Flow cytometry and apoptosis experiments showed that these complexes induced apoptosis of two different cancer cell lines (HeLa and KB cells), demonstrating a significant cancer cell inhibitory rate. Finally, a further molecular docking technique was employed to confirm the binding of the complexes towards the molecular target DNA.

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“…For the gel electrophoresis experiment, pBR322 DNA was treated with the complexes in Tris buffer (50 mM Tris–acetate, 18 mM NaCl buffer, pH = 7.2), and the contents were incubated for 1 h at room temperature . Each sample was electrophoresed for 3 h at 90 V on 0.8% agarose gel in Tris–acetate buffer.…”

Section: Methodsmentioning

confidence: 99%

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

Zhu

Wang

Meng

et al. 2018

Applied Organom Chemis

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Two new complexes, [Ho(L) 2 NO 3 ] n (1) and [Co(L′) 2 Cl 4 ] n (2) (HL = 3,5bis(triazol-1-yl)benzoic acid, HL′ = 2,4-bis(triazol-1-yl)benzoic acid), have been synthesized and characterized. Interactions with DNA through absorption titration experiments, fluorescence spectra, viscosity measurements and a molecular docking study were examined. The results suggested that complexes 1 and 2 interact with DNA in a partial intercalation mode. DNA binding affinity was determined using k b values, which indicated that the binding activity of the complexes to DNA was complex 2 (k b = 1.93 × 10 4 ) > complex 1 (k b = 1.06 × 10 4 ). Gel electrophoresis assay demonstrated that the complexes have the ability to cleave pBR322 DNA. Apoptotic assay indicated that the complexes can induce programmed death of Hela cells (human cervix carcinoma cells). A cytotoxicity study indicated that complex 2 shows a greater inhibitory rate of Hela cells than complex 1 and the cytotoxicity of both 1 and 2 showed time dependence. Especially, the efficacy of complex 2 was shown to be higher than that of cisplatin at 72 h.

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Synthesis, molecular structure, biological properties and molecular docking studies on MnII, CoII and ZnII complexes containing bipyridine–azide ligands

Cited by 66 publications

References 72 publications

Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

Mono- and binuclear copper(II) complexes of the bipyridine ligand: Structural, electrochemical and biological studies

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4‐bis (pyrazol‐1‐yl) terephthalic acid

Two Ho(III) and Co(II) complexes constructed from bis(triazol‐1‐yl)benzoic acid with structurally similar carboxyl ligands: Syntheses, structures and biological activities

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