Synthesis, nucleic acid binding and cytotoxicity of polyethyleneimine-copper(II) complexes containing 1,10-phenanthroline and l-valine

Lakshmipraba, Jagadeesan; Arunachalam, S.; Gandi, Devadas A.; Thirunalasundari, Thyagarajan

doi:10.1016/j.ejmech.2011.04.033

Cited by 37 publications

(27 citation statements)

References 57 publications

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“…Similarly, stronger RNA binding compared to DNA was found for the complex cis-[Co(trien)(4CNP)(DA)] 3+ (trien = triethylenetetramine, 4CNP = 4-cyanopyridine, DA = dodecylamine) [127]. There are also a few recent reports on the interaction of Cu(II) containing polymers and surfactants with RNA [128,129]. For example, the water soluble copper(II) complex [Cu(phen)(sal-ala)(DA)] (phen = 1,10-phenanthroline, salala = salicylalanine, DA = dodecylamine) was shown able to bind similarly DNA and RNA via intercalation driven by hydrophobicity of the ligands [128].…”

Section: A Variety Of Metal Complexes Showed Different Dna Vs Rna Binmentioning

confidence: 83%

“…In the sections below some recent advances in non-covalent binding of metal complexes to RNA are described and discussed. In particular, the following aspects are covered: (i) the use of metal complexes as RNA structural probes [40,107,108] (Section 4.1); (ii) the structure of a metal complex interacting with an RNA three-way junction [41] (Section 4.2); (iii) the development of metal complexes targeting viral RNA [109][110][111][112] (Section 4.3); (iv) the combination of metal complexes with small RNA-binding organic molecules (Section 4.4) [113][114][115][116][117]; (v) the use of RNA-targeting metal complexes in cell imaging [42,43,[118][119][120][121] (Section 4.5); (vi) comparison between DNA and RNA binding properties of some metal complexes [122][123][124][125] (Section 4.6); (vii) the RNA binding ability of some metal surfactants and metal polymers [126][127][128][129] (Section 4.7) and (viii) the binding of metal complexes to RNA triplexes [46,[130][131][132][133] (Section 4.8).…”

Section: Non-covalent Binding Of Metal Complexes To Rnamentioning

confidence: 99%

“…Also, DNA and RNA binding properties of various polyethylenimine copper(II) complexes of general formula [Cu(phen)(Lval)(BPEI)]Cl · H 2 O (phen = 1,10-phenanthroline, L-val = L-valine, BPEI = branched polyethyleneimine) were studied. The polymers interact similarly with CT-DNA and yeast tRNA, mostly through surface binding [129].…”

Section: A Variety Of Metal Complexes Showed Different Dna Vs Rna Binmentioning

confidence: 99%

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Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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Targeting nucleic acids with metal complexes is an exciting and widely explored field of research. Following the discovery of the anticancer drug cisplatin, a number of metal complexes have been designed, synthesised, and tested for their DNA binding properties. On the contrary, the interaction of metal complexes with RNA has been much less investigated. RNA is an essential biomolecule, involved in a variety of crucial cellular functions, which offers a much wider structural diversity than DNA. As such, RNA represents an attractive target for the design and the development of structure-selective therapeutic and diagnostic agents. A few recent publications describe the ability of various metal complexes to interact with RNA, and the binding of cisplatin and derivatives to RNA is being currently investigated. This short review offers an overview of some recent advances on both covalent and non-covalent interactions of metal complexes with RNA and addresses the potential of targeting RNA non-duplex structures.

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Section: A Variety Of Metal Complexes Showed Different Dna Vs Rna Binmentioning

confidence: 83%

Section: Non-covalent Binding Of Metal Complexes To Rnamentioning

confidence: 99%

Section: A Variety Of Metal Complexes Showed Different Dna Vs Rna Binmentioning

confidence: 99%

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Covalent and non-covalent binding of metal complexes to RNA

Alberti

Zampakou

Donghi

2016

Journal of Inorganic Biochemistry

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“…PEI is a polymer that contains a large amount of amines and forms a stable complex with copper ions [29,30]. Also, PEI is known to interact effectively with CNTs through charge-transferred physisorption [31].…”

Section: Resultsmentioning

confidence: 99%

Enhancement of electrical conductivity of carbon nanotube fibers by copper sulfide plating

Kim

et al. 2015

Fibers Polym

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The present study aimed to enhance the electrical conductivity of carbon nanotube (CNT) fibers by introducing copper sulfide (CuS) into them. CuS forms a very stable compound with an electrical conductivity as high as 10 6 S/m, and it was introduced into CNT fibers by treating them with polyethyleneimine (PEI) to introduce amine groups on the CNTs. The CNT fibers were then treated with a solution of copper sulfate/sodium thiosulfate, which increased their electrical conductivity by ≥100 % (4×10 5 S/m) relative to that of untreated CNT fibers. This study also examined how the CuS plating changed the structure, morphology, and mechanical properties of CNT fibers. The results indicate that the modulus of elasticity of CuS-plated CNTs increased by 2.86 times (11.34 N/tex) and the elongation-at-break decreased by half.

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“…The investigation of copper complexes' interaction with nucleic acids suggests that DNA does not represent the main biological target for this class of metal compounds. Another mechanisms of action base on intercalation and cleavage of DNA or apoptosis induction , …”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

Kalinowska-Lis

Szabłowska-Gadomska

Lisowska

et al. 2017

Zeitschrift anorg allge chemie

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The cytotoxic and antimicrobial activity of a series of six copper(II) complexes with phosphate and hydroxymethyl derivatives of pyridine and benzimidazole were investigated. The complexes and the corresponding free ligands were tested against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Pseudomonas aeruginosa ATCC 15442, Escherichia coli ATCC 25922, Proteus hauseri ATCC 13315, and Candida albicans ATCC 10231. Among the tested copper(II) complexes, compounds 2 and 5 containing 1H‐benzimidazol‐2‐ylmethyl diethyl phosphate and 2‐(hydroxymethyl)benzimidazole as ligands, respectively, were most active and limited the growth of S. aureus, E. coli, and C. albicans by 30–60 % according to concentration and microorganism. The in vitro cytotoxic activity of the CuII complexes and free ligands towards cancerous B16 (murine melanoma) and non‐cancerous 10T1/2 (murine fibroblasts) cell lines was determined. The 10T1/2 cells were treated with the compounds at concentrations equal to IC50 values for B16 cells. In spite of the use of relatively high concentrations of the complexes, the viability of 10T1/2 cells was very high, ca. 80 % in some cases. Stability of the CuII complexes was evaluated in water solutions by UV/Vis spectroscopy. The copper(II) complex of 4‐(hydroxymethyl)pyridine was synthesized and identified.

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Synthesis, nucleic acid binding and cytotoxicity of polyethyleneimine-copper(II) complexes containing 1,10-phenanthroline and l-valine

Cited by 37 publications

References 57 publications

Covalent and non-covalent binding of metal complexes to RNA

Covalent and non-covalent binding of metal complexes to RNA

Enhancement of electrical conductivity of carbon nanotube fibers by copper sulfide plating

Cytotoxic and Antimicrobial Properties of Copper(II) Complexes of Pyridine and Benzimidazole Derivatives

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