Synthesis of 2,3-Dihydroquinazoline-4(1H)-ones

Straightforward Hantzsch four‐ and three‐component condensation in the presence of triphenyl(propyl‐3‐sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a reusable and green mild ionic liquid catalyst

“…NMR spectra were obtained with a Fourier transform NMR Bruker AV-500 spectrometer in DMSO-d 6 , with shifts measured relative to tetramethylsilane; coupling constants (J) were measured in Hz. Melting points were determined with an Electrothermal 9100.…”

Eco‐friendly and Efficient Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones

“…According to observation of evolution in the reaction conditions and also other reported mechanism in the literature, 18 interaction of SiO 2 -FeCl 3 as catalyst and isatoic anhydride to produce a reactive intermediate (I). The N-nucleophilic primary amine attacks on the carbonyl unit of I to produce a reactive intermediate II, which in turn affords III through decarboxylation reaction.…”

“…All known products have been reported previously in the literature and were characterized by comparison of IR and NMR spectra with authentic samples. [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] reaction conditions, the scope and efficiency of the reaction were explored for the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives through direct condensation of aromatic aldehydes (1 mmol), anthranilamide (1 mmol) and SiO 2 -FeCl 3 (0.005 g) as catalyst under solvent-free conditions (Table 3). We can compare results of preparation of 2,3-dihydroquinazolin-4(1H)-one derivatives through the direct cyclocondensation of a) one-pot threecomponent cyclocondensation of isatoic anhydride, ammonium acetate (or primary amines) and aldehydes (Table 2); and b) anthranilamide and aldehydes (Table 3) using silica supported ferric chloride (SiO 2 -FeCl 3 ) as catalyst under solvent-free conditions.…”

Synthesis, characterization and antimicrobial studies of new 2-(2-chloroquinolin-3-yl)-3-(substituted phenyl/pyridinyl)quinazolin-4(3H)-one derivatives using l-proline as a catalyst

“…Various synthetic routes are reported for synthesizing quinazolinone derivatives using starting materials like anthranilic acid, benzoxazines, anthranilates and isatoic anhydride (Wang et al, 2003;Abdel-Jalil et al, 2004;Peyman et al, 2006), yet the hunt for a convenient synthetic method is going on to improve the yield and reaction time in the on hand methods (Yi et al, 2003;Potewar et al, 2005). Among all of these, isatoic anhydride has been proved very important precursor for synthesizing 2,3-disubstituted quinazolinones under various reaction conditions (Dabiri et al, 2005;Kumari et al, 2012;Shaterian et al, 2010).…”