Synthesis of chiral core based triazole dendrimers with m-terphenyl surface unit and their antibacterial studies

Thirunarayanan, Ayyavu; Raja, Sebastian; Mohanraj, G; Rajakumar, Perumal

doi:10.1039/c4ra04967e

Cited by 20 publications

(4 citation statements)

References 43 publications

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“…The highly selective biological actions of chiral molecules due to specific enzymatic associations offer countless applications in drug delivery systems. Thirunarayanan et al synthesized chiral core-based triazole dendrimers through a click chemistry approach for specific antibacterial properties to overcome resistance [ 24 ].…”

Section: Types Of Dendrimersmentioning

confidence: 99%

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Filipczak

Yalamarty

et al. 2021

Molecules

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Dendrimers comprise a specific group of macromolecules, which combine structural properties of both single molecules and long expanded polymers. The three-dimensional form of dendrimers and the extensive possibilities for use of additional substrates for their construction creates a multivalent potential and a wide possibility for medical, diagnostic and environmental purposes. Depending on their composition and structure, dendrimers have been of interest in many fields of science, ranging from chemistry, biotechnology to biochemical applications. These compounds have found wide application from the production of catalysts for their use as antibacterial, antifungal and antiviral agents. Of particular interest are peptide dendrimers as a medium for transport of therapeutic substances: synthetic vaccines against parasites, bacteria and viruses, contrast agents used in MRI, antibodies and genetic material. This review focuses on the description of the current classes of dendrimers, the methodology for their synthesis and briefly drawbacks of their properties and their use as potential therapies against infectious diseases.

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Section: Types Of Dendrimersmentioning

confidence: 99%

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Filipczak

Yalamarty

et al. 2021

Molecules

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“…Chiral dendrimers have potential use in drug delivery, catalysis (including enantioselective catalysis), as catalyst supports, phase transfer catalysts, and as membrane reactors as well as a variety of other applications. (S)-BINOL cored dendrimers show biological activities, such as antibacterial, 10,11 anti-inammatory, 12 anti-microbial, 13 and anticancer. 14 Thus, the (S)-BINOL unit plays an important role in biology as well as in liquid crystals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, optical, electrochemical properties and anticancer activity of (S)-BINOL cored triazole bridged dendrimers decorated with rhodamine B surface group

Savithri

Rajakumar

2019

RSC Adv.

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“…The BINOL ring framework is among these bioactive scaffolds that have been considered one of the mainstays in providing novel chemical scaffolds for many drugs. Chiral bicyclic macrocycles, Imidazole based dicationic macrocycles, chiral dendrimers,, Imidazolium salts at 3,3’ substitution on BINOL and [2,1‐ b :1′,2′‐ d ][1,6]dioxacycloalkenes having BINOL as core unit show antibacterial activity. Very few reports are available on 3,3′‐disubstituted chiral ( R )‐BINOL.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of New Chiral (R)‐BINOL Derivatives under Microwave Irradiation and Evaluation of Their Antibacterial and α‐Glucosidase Inhibitory Activity

Ankireddy¹,

Paidikondala²,

Gundla³

et al. 2019

ChemistrySelect

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Series of new 3,3’‐disubstituted chiral (R)‐BINOL compounds have been synthesized with good yields and short reaction time under microwave‐irradiation. The titled compounds showed great antibacterial activity against gram‐positive and gram‐negative organisms. The results indicated that two compounds (R)‐3,3′‐bis(3,5‐difluorophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 a) and (R)‐3,3′‐bis(4‐nitrophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 d) which bearing fluoro and nitro substitution on phenyl group has displayed highest inhibition against pathogens. All the derivatives evaluated in vitro against α‐glucosidase. The results indicates that all the target compounds have significant inhibitory activity and more potent than standard drug Acarbose (IC50 = 586.391 ± 14.017 μM). (R)‐3,3′‐bis(3,5‐dichlorophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 b), (R)‐3,3′‐bis(3,5‐difluorophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 a), (R)‐3,3′‐bis(4‐nitrophenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 d) and (R)‐3,3′‐bis(3,5‐dimethylphenyl)‐[1,1′‐binaphthalene]‐2,2′‐diol (6 f) compounds shows strong inhibitors of α‐glucosidase, with the IC50 values of 25.341 ± 0.009 μM, 29.215 ± 0.017 μM, 30.294 ± 0.012 μM and 32.402 ± 0.041 μM, respectively.

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Synthesis of chiral core based triazole dendrimers with m-terphenyl surface unit and their antibacterial studies

Cited by 20 publications

References 43 publications

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Developments in Treatment Methodologies Using Dendrimers for Infectious Diseases

Synthesis, optical, electrochemical properties and anticancer activity of (S)-BINOL cored triazole bridged dendrimers decorated with rhodamine B surface group

Synthesis of New Chiral (R)‐BINOL Derivatives under Microwave Irradiation and Evaluation of Their Antibacterial and α‐Glucosidase Inhibitory Activity

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