Synthesis of Chrysin Based Cationic Lipids: Plasmid Delivery and Transgene Expression

Synthesis of Some New Chrysin Derivatives and Their Biological Assessment as Antibacterial, Antibiofilm and Antifungal Agent

“…Amongst various naturally occurring flavonoids, very few semi-synthetic derivatives of chrysin have been developed by different researchers and evaluated for broad spectrum biological activities viz. antimicrobial [17,19], anticancer [25][26][27][28], anti-inflammatory, vasodilating, immune modulating, neuro-protective, antidiabetic and many more [17,[29][30][31]. The encouraging biological profiles of the flavonoids particularly of chrysin and in continuation of our current research interests [32] on searching and development of antimicrobial agent from natural resources led us to extend our work towards the synthesis of some new chrysin derivatives and their biological evaluations.…”

“…Thus, development of new types of antibacterial agents or enhancement of the activity of existing drugs is an urgent need in combating such pathogenic strains. Researchers throughout the world are engaged to develop potential antimicrobial lead compounds via chemical synthesis [7][8][9][10][11][12][13][14][15][16] as well as via the structural modulation of plant secondary metabolites [17][18][19][20]. It is well established that natural products, particularly heterocyclic compounds viz.…”

“…alkaloids, flavonoids and their semi synthetic derivatives have played a vital role in drug discovery and development [2,18,[21][22][23][24]. Semi synthetic flavonoid derivatives have shown to possess numerous and excellent biological activities [17,19,20]. Amongst various naturally occurring flavonoids, very few semi-synthetic derivatives of chrysin have been developed by different researchers and evaluated for broad spectrum biological activities viz.…”