Synthesis of heterocyclic compounds and its applications

Abstract

The octahedral ruthenium(II) complexes [Ru(L n )(PPh 3 ) 2 Cl 2 ] [L n = biphenyl furanyl pyridine derivatives] were synthesized and characterized using LC-MS, IR spectroscopy, elemental analysis and magnetic measurements. Complexes show enhancement in antibacterial activity compared to free ligands. From the binding mode investigation by absorption titration and viscosity measurement, it is observed that complexes bind to DNA via intercalation and also complexes promote the cleavage of supercoiled pUC19 plasmid DNA. Cytotoxicity analysis shows 100% mortality of Brine shrimp after 48 h. ª 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Structural Characterization, DFT Calculations, Metal Uptake, Fluorescence, Antimicrobial and Molecular Docking Studies of Novel Co(II) and Ni(II) Complexes with NNS Tridentate Schiff base Ligand

“…Heterocyclic compounds were the most abundant in nature and were required for a wide range of applications in biology including antibacterial, antifungal, anticancer, antioxidant, anti-in ammatory activity, and also in analytical processes [13][14][15][16][17]. These heterocycle-containing compounds have important properties in the elds of material science and biological systems [18,19].…”