Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies

Raghavendra, K. R.; Renuka, N.; Kameshwar, Vivek H.; Srinivasan, Bharath; Kumar, K. Ajay; Shashikanth, S.

doi:10.1016/j.bmcl.2016.06.005

Cited by 20 publications

(9 citation statements)

References 22 publications

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“…The dimension of the grid was in such a manner that the grid covers the whole target biomolecule. Using Extra-precision (XP) docking and scoring each compound were docking into the receptor grid and the docking calculation were judged based on the Glide score [19]. In FC 6 H 3 (SCN)N=CHC 6 H 4 OCl, the average length of the N2=C8 bond is 1.267 (6), and bond angle of N2-C8-C9 is 123.8(4) ( Table 2), obtained as expected.…”

Section: Molecular Dockingsupporting

confidence: 56%

2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol; synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies

Kumar

Chidananda

Doddarevanna

et al. 2017

Journal of Molecular Structure

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A new imine-based molecule 2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4chlorophenol (FBt) was synthesized by microwave and conventional method. It was structurally characterized by spectral techniques (NMR, FT-IR, LC-MS and electronic absorption), elemental analysis and single-crystal X-ray diffraction methods. Hirshfeld surface analysis was employed to ensure the existence of intermolecular interactions in FBt structure. A preliminary in vitro susceptibility test against two pathogenic fungi with respect to standard has shown that the ligand is proved to be a potent antifungal agent. Since the carrying of a drug by BSA may effect on its structure and action, the investigation on the interaction between model protein BSA and FBt was carried out by employing UV-Vis and fluorescence spectroscopy. The characteristics of the binding, i.e., binding constant, number of binding sites, and nature of binding were determined. Besides, the Förster's parameters associated with the binding process were calculated. Molecular docking was also carried on interaction study of the FBt with BSA.

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Section: Molecular Dockingsupporting

confidence: 56%

2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol; synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies

Kumar

Chidananda

Doddarevanna

et al. 2017

Journal of Molecular Structure

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“…Compounds (4d) and (4f) of parental nucleus, imparted a specific geometrical space around the Cu-Zn binding loop. Among which activity of SOD gets exuberated during the process followed by catalase [15]. Activity of Cu-ZnSOD has studied based on protein engineering to increase activity by modifying the electrostatic environment of the active site.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Formylpyrazole Analogues: Synthesis, Antimicrobial, Antioxidant and Molecular Docking Studies

Gurunanjappa¹,

Vivek²,

Kariyappa³

2017

Asian J. Chem.

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A series of six new 3-(1-hydroxynaphthalen-2-yl)-1-aryl-1H-pyrazole-4-carbaldehyde derivatives were synthesized by Vilsmeier-Haack reaction of phenyl hydrazones. The new compounds were characterized by spectral studies and elemental analysis. Synthesized compounds were evaluated in vitro for their antimicrobial and antioxidant susceptibilities. The results suggest that the compounds with methyl and methoxy substitutions in the aromatic ring have good in vitro antimicrobial activities and those with methyl, methoxy and no substitutions possess promising DPPH and hydroxyl free radical scavenging abilities.

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“…Compounds 2d and 2f of parental nucleus, imparted a specific geometrical space around the Cu-Zn binding loop. Among which activity of SOD gets exuberated during the process followed by CAT [17]. Activity of Cu-ZnSOD has studied based on protein engineering to increase activity by modifying the electrostatic environment of the active site.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Hydoxyl radical scavenging ability of the compounds 2a-f was performed by assessed by known method [17]. Mixture of phosphate buffer (0.…”

Section: Hydroxyl Radical Scavenging Assaymentioning

confidence: 99%

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

Gurunanjappa

Ningappa

Kariyappa

2016

Chemical Data Collections

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Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies

Cited by 20 publications

References 22 publications

2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol; synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies

2-((E)-(6-fluorobenzo[d]thiazol-2-ylimino) methyl)-4-chlorophenol; synthesis, characterization, crystal structure, Hirshfeld surface analysis and BSA binding studies

Bioactive Formylpyrazole Analogues: Synthesis, Antimicrobial, Antioxidant and Molecular Docking Studies

Synthesis of pyrazole fused pyran analogues: Antimicrobial, antioxidant and molecular docking studies

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