Synthesis of N-Methylene Linker Containing Phthalimide Bearing-1<i>H</i>-1,2,3-Triazole by Click Chemistry Approach: Anticancer Activity in Human Cells

Mori, Navneet P.; Parmar, Priti K.; Khedkar, Vijay M.; Khunt, Ranjan C.

doi:10.1080/10406638.2022.2101487

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…Structure‐activity relationship revealed that the electronegative substitution of bromine at ortho position of the phenyl ring increased in the activity was observed whereas chlorine, fluorine substitution decreases the potency. Other substituents at the phenyl ring displayed the growth inhibition ranging from 0.78–6.65 %, which was much lesser than the compound 1 [30] . At same pace, El‐Sayed et al .…”

Section: 23‐triazole Derivatives With Antifungal Activity Against As ...mentioning

confidence: 87%

“…Other substituents at the phenyl ring displayed the growth inhibition ranging from 0.78-6.65 %, which was much lesser than the compound 1. [30] At same pace, El-Sayed et al reported and synthesised a N-bridgedtriazolo [3,4-b]thiadiazine and triazolo [3,4-b]thiadiazole derivatives. Among them compound 2 was found to be most potent with MIC value of 15.16 μmol/mL.…”

Section: 23-triazole Derivatives With Antifungal Activity Against As ...mentioning

confidence: 99%

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1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

Singh

Sharma

et al. 2023

Chemistry & Biodiversity

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Candida infections are most prominent among fungal infections majorly target immunocompromised and hospitalized patients and cause significant morbidity and mortality. Candida albicans is the notorious and most prevalent among all pathogenic Candida strains. Its emerging resistance toward available antifungal agents making it hard to tackle and emerging as global healthcare emergency. Simultaneously, 1,2,3-triazole nucleus is a privileged scaffold that is gaining importance in antifungal drug development due to being a prominent bioactive linker and isostere of triazole based antifungal class core 1,2,4-triazole. Numerous reports have been updated in scientific literature in last few decades related to utilization of 1,2,3-triazole nucleus in antifungal drug development against Candida albicans. Present review will shed light on various preclinical studies focused on development of 1,2,3-triazole derivatives targeting Candida albicans along with brief highlight on clinical trials and newly approved drugs. Structure-activity relationship has been precisely discussed for each architect along with future perspective that will help medicinal chemists in design and development of potent antifungal agents for tackling infections derived from Candida albicans.

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Section: 23‐triazole Derivatives With Antifungal Activity Against As ...mentioning

confidence: 87%

Section: 23-triazole Derivatives With Antifungal Activity Against As ...mentioning

confidence: 99%

1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

Singh

Sharma

et al. 2023

Chemistry & Biodiversity

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An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential

Raman,

Aslam,

Awasthi

et al. 2024

Mol Divers

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Synthesis of N-Methylene Linker Containing Phthalimide Bearing-1H-1,2,3-Triazole by Click Chemistry Approach: Anticancer Activity in Human Cells

Cited by 2 publications

References 53 publications

1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

1,2,3‐Triazole Derivatives as an Emerging Scaffold for Antifungal Drug Development against Candida albicans: A Comprehensive Review

An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential

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