Synthesis of new functionalized aryl‐substituted methylphosphonic and methylenediphosphonic acids and their derivatives

Abstract

The convenient syntheses of new aryl‐substituted hydroxymethylphosphonic and methylenediphosphonic acids from the aromatic aldehydes, their derivatives, and phosphorous acid esters in the presence of the effective catalysts (trimethylsilyl trifluoromethanesulfonate, zinc chloride, and cadmium iodide) were developed.

Deamination of 1-Aminoalkylphosphonic Acids: Reaction Intermediates and Selectivity

“…The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/molecules27248849/s1, The material includes detailed procedures and NMR spectra for all reactions and compounds [72][73][74][75][76][77][78][79][80][81][82][83][84][85][86][87][88].…”

Synthesis of new functionalized hydroxy‐ and aminomethylphosphinates with indan moieties

“…It should be noted that the functionalized organophosphorus acids with aryl, heterocyclic, and bicyclic moieties are of particular interest among these substances . Earlier, we described original methods for the synthesis of aminomethylenebisphosphonic acid derivatives, as well as new aryl‐substituted methylphosphonic and methylenediphosphonic acids and their derivatives using trimethylsilyl esters of trivalent phosphorus acids as highly reactive synthons. In the present work, convenient methods for the synthesis of functionalized amino‐ and hydroxymethylphosphinic acids and their derivatives, including bicyclic moieties of indan as well as aromatic and heterocyclic substitutents, are proposed via highly reactive bis(trimethylsiloxy)phosphine.…”

Synthesis of new organophosphorus‐substituted fulvenes with indenyl moieties

“…The original synthesis of substituted fulvenes is associated with the radical cyclization of substituted o ‐phenylenediynes in the presence of tributyltin hydride [7]. Preliminary brief data on the synthesis of organophosphorus benzofulvenes were published by us earlier (cf [8a]…”

“…Recently we developed the convenient methods for preparing several organophosphorus compounds with various functional groups and heterocyclic moieties via using of trimethylsilyl esters of organophosphorus acids. [8b]…”