Synthesis of new heterocyclic compounds having 1,2,3‐triazole and isoxazole rings in a single molecule

Abstract

Five series of new heterocyclic compounds of 1,2,4‐triazole Mannich bases, 1,3,4‐oxadiazole Mannich bases, 1,3,4‐oxadiazolines, 1,2,4‐triazolo[3,4‐b]1,3,4‐thiadiazines and 1,2,4‐triazolo[3,4‐b]1,3,4‐thiadiazoles, in which 1,2,3‐triazolyl and isoxazolyl have been united, were synthesized from the intermediate of 5‐methyl‐3‐(2‐phenyl‐2H‐1,2,3‐triazol‐4‐yl)isoxazole‐4‐carbohydrazide, Their structures were established by spectroscopy.

Synthesis of Hybrid Isoxazole‐triazole Compounds as Potential Antiproliferative Agents

“…[14] To the best of our knowledge, a few isoxazole-triazole hybrids have been synthesized. [11,13,[15][16][17][18] Some of them exhibited noticeable biological activity at that. [11,17,18] Thus the leader of benzo[d]isoxazole derivatives I with triazole fragment incorporated into a single framework revealed very good anti-tubercular activity (MIC = 6.16 μM) against MTB H37Rv strain (Figure 1).…”

Synthesis andIn VitroCytotoxic Activity of Novel Triazole-Isoxazole Derivatives

“…Up to now, a few efforts has been efficiently developed for the synthesis of compounds having both triazol and isoxazole skeletons . Recently, a series of N ‐((1‐benzyl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl)arylamides was synthesized by Stefely et al as efficient inhibitors of cancer cell growth .…”