Synthesis of New Pyrane and Cyclohexanone Derivatives on the Base of Some Knoevenagel Adducts

Abstract

The formation of cyclohexanone and 3,4-dihydro-2H-pyran derivatives by using of Michael addition reaction between the 3-(4-tolyl)-, 3-(4-methoxyphenyl)-, 3-phenyl-, 3-pyridinyl-2-(thiophene-2-carbonyl)acrylonitriles or 3-(4-tolyl)-, 3-(thiophen-2-yl), and 2-(4-bromobenzoyl)-3-(4-fluorophenyl)acrylonitriles to the acetoasetanilid were observed. Structures of all synthesized compounds confirmed by nuclear magnetic resonance spectroscopy and X-Ray analysis.

Crystal structure and Hirshfeld surface analysis of 3-cyano-4-hydroxy-2-(4-methylphenyl)-6-oxo-N-phenyl-4-(thiophen-2-yl)cyclohexane-1-carboxamide 0.04-hydrate

“…They are valuable building blocks in organic synthesis and coordination complexes (Shokova et al, 2015;Ma et al, 2015;Gurbanov et al, 2017Gurbanov et al, , 2018Mittersteiner et al, 2020). Cyclocondensation reactions of -diketones with various reagents mainly lead to the formation of carbocyclic and heterocyclic compounds (Mamedov et al, 2013(Mamedov et al, , 2019Naghiyev et al, 2019;Naghiyev, 2020). Being a carbocyclic system, cyclohexanone derivatives are scaffolds in many synthetic and natural products.…”

Synthesis and biological assessment of some fused Pyran derivatives

“…Pyran derivative arena has a wide range of biological actions, including antitumor [4], antimicrobial [5], antiviral [6], and so on. In order to continue our efforts in the advancement of environmentally benign synthetic approaches for the design and synthesis of heterocyclic compounds [7], complex synthetic procedures with extraction and purification at every stage result in synthetic ineptitude and the generation of enormous quantities of waste due of lengthy reaction times and costly catalysts required for the synthesis of pyran derivatives [8]. To tackle this issue, a multi‐component process was employed to synthesize pyran derivatives [9].…”