Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides

Click chemistry has provided us with access to DNA and RNA analogues with non-natural triazole internucleoside linkages. The bond periodicity of the oligonucleotides was designed to enforce duplex formation with natural congeners, and the non-cleavable linkages protect the oligomers against nuclease digestion. This account reviews the progress of the triazole-linked analogues over the past five years. Reinforced by their synthetic robustness, these analogues may find various utilities as tools for exploratory research.

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Triazole‐Linked Analogues of DNA and RNA (^TLDNA and ^TLRNA): Synthesis and Functions

Isobe

Fujino

2013

The Chemical Record

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Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides

Cited by 1 publication

References 15 publications

Triazole‐Linked Analogues of DNA and RNA (^TLDNA and ^TLRNA): Synthesis and Functions

Triazole‐Linked Analogues of DNA and RNA (^TLDNA and ^TLRNA): Synthesis and Functions

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Synthesis of nonionic ether-backbone analogues of RNA from pseudooligosaccharides

Cited by 1 publication

References 15 publications

Triazole‐Linked Analogues of DNA and RNA (TLDNA and TLRNA): Synthesis and Functions

Triazole‐Linked Analogues of DNA and RNA (TLDNA and TLRNA): Synthesis and Functions

Contact Info

Product

Resources

About

Triazole‐Linked Analogues of DNA and RNA (^TLDNA and ^TLRNA): Synthesis and Functions

Triazole‐Linked Analogues of DNA and RNA (^TLDNA and ^TLRNA): Synthesis and Functions