Synthesis of Novel Polyfunctionally Substituted Thieno[2,3‐c]pyridazines

In present work, five 1,3,4-thiadiazole compounds were synthesized. The prepared compounds were identified by CHNS analysis, FT-IR and 1 H NMR spectroscopy. The corrosion rates in the presence of thiadiazole as a steel corrosion inhibitor in the cooling water system which taken from South Fertilizer Company, Basra, Iraq were measured by the weight loss method and potentiodynamic polarization measurements. The weight loss method was studied in different times (1-5 h) and in 303 to 333 K temperature range. Results obtained revealed that thiadiazole compounds performed as a corrosion inhibitor for mild steel in this medium and its efficiency attains to 86.55 % at 5 × 10 -3 M at 303 K and by potentiodynamic polarization measurements its efficiency attains to 85.35 % in the same conditions. The apparent activation energies, enthalpies and entropies of the dissolution process and the free energies were determined and discussed.

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“…The IR data of the parent thiadiazole compound showed a band at 2766 cm -1 which is characteristic of the S-H stretching [18,19] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of Some Thiadiazole Compounds as New Corrosion Inhibitors for Mild Steel in Cooling Water

Jasim¹,

Abduljaleel²,

Fayadh³

2017

Asian J. Chem.

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“…The capability to scavenge the DPPH radical was calculated using the following equation [8]: H-NMR spectra of the prepared azo dyes were performed in deuterated DMSO solutions with tetramethylsilane as an internal standard. All these spectra showed a peak at 2.5 ppm which was due to DMSO solvent, and some spectra showed a sharp peak at 3.33 ppm due to dissolved water in DMSO [15,16]. Figs.…”

Section: Antioxidant Activitymentioning

confidence: 92%

Antioxidant Activity of Some Newly Prepared Symmetrically Azo Dyes Derived From Sulfa Drugs

Muhammad‐Ali

Salman

Jasim

2019

Asian J Pharm Clin Res

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Objective: Sulfa drugs (sulfonamides) were the first type of drugs largely medically used for preventive and chemotherapeutic agents against various types of diseases. To the date, much research has been directed toward the synthesis sulfa drug derivatives such as azo‑sulfa drug compounds. The aim of the present study is to synthesize of azo‑sulfa compounds as antioxidant agents. Methods: First, three of sulfa drugs react with 4‑methoxy‑1,2‑Naphthoquinone in aqueous medium by stirring at room temperature to give symmetrically azo‑sulfa compounds. The colored compounds which formed were examined their structures by infrared and proton nuclear magnetic resonance spectral techniques. Results: Three symmetrically azo‑sulfa compounds were tested as antioxidant agents compared with ascorbic acid (AA) using 2,2‑diphenyl‑1‑picrylhydrazyl method. The results indicated that these compounds had good activities (57.79–73.69%) at 30 μg/ml, which had less activity than AA (81.34%) at the same concentration. These results referred the IC50 which had values (15.23–21.35 μg/ml), whereas AA had 7.59 μg/ml. Conclusion: Attachment of heterocyclic rings containing nitrogen and oxygen (isoxazole) on the azo‑sulfa compounds can enhance the antioxidant activity as compared with the heterocyclic rings containing nitrogen only (pyrimidine) and without heterocyclic rings, which enhanced the lipophilicity which may increase the bioavailability and efficacy of the drug.

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“…Treatment of 2 with phenyl 7-fluoro-4-chromone-3-sulfonate in presence of sodium acetate and glacial acetic acid at 100°C afforded a mixture of 7-fluoro-2H- [1,2] …”

Section: Scheme 11mentioning

confidence: 99%

“…The β-functional nitrile [1][2][3][4] moiety of the molecule is a favorable unit for addition followed by cyclization or via cycloaddition with numerous reagents providing heterocyclic compounds of different ring sizes with one or several heteroatoms that are interesting as pharmaceuticals, 5,6 as herbicides, 7 as antibacterial agents, 8 and as dyes. 9,10 Their reactions with dinucleophiles usually result in the formation of polycyclic ring systems which may be the skeleton of important heterocylic compounds.…”

Section: Introductionmentioning

confidence: 99%

Utility of cyanoacetic acid hydrazide in heterocyclic synthesis

Bondock¹,

El-Tarhoni²,

Fadda³

2006

Arkivoc

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Synthesis of Novel Polyfunctionally Substituted Thieno[2,3‐c]pyridazines

Abstract: 4‐Cyano‐5,6‐dimethylpyridazin‐3‐(2H)‐thione 3b was used as a key intermediate for the synthesis of novel polysubstituted thieno[2,3‐c]pyridazines.

Cited by 19 publications

References 7 publications

Synthesis and Characterization of Some Thiadiazole Compounds as New Corrosion Inhibitors for Mild Steel in Cooling Water

Synthesis and Characterization of Some Thiadiazole Compounds as New Corrosion Inhibitors for Mild Steel in Cooling Water

Antioxidant Activity of Some Newly Prepared Symmetrically Azo Dyes Derived From Sulfa Drugs

Utility of cyanoacetic acid hydrazide in heterocyclic synthesis

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