Synthesis of organs:
            <i>In vitro</i>
            or
            <i>in vivo</i>
            ?

Yannas, Ioannis V.

doi:10.1073/pnas.180313497

Cited by 16 publications

(12 citation statements)

References 13 publications

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“…50 The regenerated skin, however, lacked hair follicles and sweat glands. [43][44][45][46][47][48][49][50][51][52] Similar results have been reported in swine 52 and in several clinical trials with humans; some of these are referred to in this text. [53][54][55][56][57][58][59] Although this article is focused on skin wound healing, it is useful to consider briefly the relative success in inducing peripheral nerve regeneration using a different scaffold.…”

Section: Summary Of Mechanistic Differences Between Early Fetal Healisupporting

confidence: 68%

“…Analysis of a large number of protocols that have been used to induce skin regeneration has shown that the investigator need not supply fibroblasts and growth factors to induce stroma regeneration. 43,46 The wound environment provides the required endogenous reactantsprimarily fibroblasts and growth factors that contribute to synthesis of stroma. However, the available evidence shows ORGAN REGENERATION that exogenous addition of the appropriate scaffold is required for stroma regeneration.…”

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

“…Autologous keratinocytes can be supplied in the form of cells seeded inside a highly porous scaffold. 45,46 When the wound is grafted with a keratinocyte-seeded scaffold, epidermis and stroma are regenerated simultaneously, greatly speeding up regeneration of the organ. [45][46][47][48][49] An extensive analysis of the available data has shown that regenerated skin is similar, but not identical, in morphology and function, to adult normal skin.…”

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

“…45,46 When the wound is grafted with a keratinocyte-seeded scaffold, epidermis and stroma are regenerated simultaneously, greatly speeding up regeneration of the organ. [45][46][47][48][49] An extensive analysis of the available data has shown that regenerated skin is similar, but not identical, in morphology and function, to adult normal skin. [43][44][45][50][51][52] The major difference between regenerated skin and normal skin at this time is the lack of appendages (hair follicles, sweat glands, etc.)…”

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

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Early Fetal Healing as a Model for Adult Organ Regeneration

2007

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Section: Summary Of Mechanistic Differences Between Early Fetal Healisupporting

confidence: 68%

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

Section: Induced Regeneration Of Skin and Other Organs In Adultsmentioning

confidence: 99%

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Early Fetal Healing as a Model for Adult Organ Regeneration

2007

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“…The requirement for a distinction between in vitro and in vivo protocols (Fig. 7.1) has important practical and theoretical implications (Yannas 2000).…”

Section: In Vitro Versus In Vivo Conditions For Synthesis Of Tissuesmentioning

confidence: 99%

Tissue and Organ Regeneration in Adults

Yannas

2015

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Skin Tissue Engineering for Regeneration

Harley

Yannas

2006

Encyclopedia of Medical Devices and Instrumentation

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Skin wounds, particularly burns, affect a large population each year. The injury response to skin wounds depends both of the severity of the wound and the animal affected. The typical organismic response to an injury at the organ‐scale is cell‐mediated wound contraction and synthesis of nonphysiologic tissue (scar); this process is termed repair. Regeneration of lost or damaged tissue describes a process marked by synthesis of physiologic (normal, functional) tissue in the wound site. With increasing organism development, wound closure depends increasingly less on regeneration and correspondingly more on contraction and scar formation. A variety of tissue engineering constructs have been utilized to prevent contraction and scar formation and induce regeneration following skin wounds. Experimental experience has identified a number of specific criteria to maximize the bioactivity of such a graft, leading to maximal regeneration. These criteria as well as the morphology, functionality, and regenerative capacity of the three tissues that comprise skin will be detailed. In addition to the description of the organismic response to skin injuries and the current and historical clinical treatments for such injuries, five specific devices developed to treat severe skin injuries, including the design and manufacture of each device as well as the attendant experimental and clinical successes, will be detailed.

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Synthesis of organs: In vitro or in vivo ?

Cited by 16 publications

References 13 publications

Early Fetal Healing as a Model for Adult Organ Regeneration

Early Fetal Healing as a Model for Adult Organ Regeneration

Tissue and Organ Regeneration in Adults

Skin Tissue Engineering for Regeneration

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