Synthesis of Per(poly)fluoroalkyl aldehydes RF(CH2)nCHO

́veˆque, Laurence Le; Blanc, Maurice; Pastor, Raphae ̈l

doi:10.1016/s0040-4039(98)02029-2

Cited by 22 publications

(18 citation statements)

References 21 publications

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“…The mass transfer coefficient measured in the flow cell is significantly higher than that observed in straight square channels. As seen in Figure 7 the experimental data are clearly above the lines representing the Le´veˆque equation (for laminar regime) [13]: …”

Section: Liquid-solid Mass Transfermentioning

confidence: 81%

Electrodiffusion diagnostics of the flow and mass transfer inside a network of crossing minichannels

et al. 2006

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The global mass transfer and the local flow structure inside a set of crossing minichannels were characterized using the electrodiffusion method. The individual square-cross channel sections (a = 1.5 mm in sides) intersect at rightangles in order to form the flow cell. An array of 39 circular platinum electrodes (0.25 mm in diameter) was flushmounted into the wall of the flow cell to investigate the wall shear rate at different locations. This array of small sensors allowed characterization of longitudinal and lateral variations in wall shear rate across the flow cell, flow distribution at the inlet and outlet sections, transition between laminar and turbulent flow regimes, and flow behaviour at the channel crossings. The results of global wall mass transfer measurements demonstrated that, from a mass transfer point of view, the flow cell exhibits similar behaviour to a porous medium.

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Section: Liquid-solid Mass Transfermentioning

confidence: 81%

Electrodiffusion diagnostics of the flow and mass transfer inside a network of crossing minichannels

et al. 2006

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“…Therefore, we assume the configuration to be set during the elimination process following either an E 2 - or E CB -mechanism. Alternatively, the outcome could also be explained by an intramolecular six-membered ring rearrangement of the corresponding enol form, as reported in related cases. ,, …”

Section: Results and Discussionmentioning

confidence: 69%

“…Previous Work on Perfluoroalk(en)ylation Reactions 33,36,46 outcome could also be explained by an intramolecular sixmembered ring rearrangement of the corresponding enol form, as reported in related cases. 42,44,54 Further investigations showed that the reaction is not only limited to the perfluorobutyl iodide but also longer chain analogues as well as difluoroiodoacetates were successfully employed (Table 2b). In the case of CF 3 I, no elimination was observed, but instead, the α-trifluoromethylated product was isolated in 53% yield.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…During our research, by aiming at perfluoroalkylations of enamines with phosphine EDA complexes, we observed the formation of tetrasubstituted, fluorinated α,β-unsaturated aldehydes. This structural motif is only rarely reported in the literature, − involving mostly the transformation of ketone derivatives. − The recent work by Beller et al provides the first generally applicable method for the synthesis of perfluoroalkenylated ketones (Scheme c) . At elevated temperatures, the addition of an excess of both pyrrolidine and substrate results in the formation of the fluorinated α,β-unsaturated ketones.…”

Section: Introductionmentioning

confidence: 99%

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Straightforward Synthesis of Fluorinated Enals via Photocatalytic α-Perfluoroalkenylation of Aldehydes

Wulkesch

Czekelius

2021

J. Org. Chem.

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(Per)fluorinated substances represent an important compound class with regard to drug design and material chemistry. We found a mild, operationally simple, and inexpensive photocatalytic perfluoroalkenylation reaction giving tetrasubstituted, highly electron-deficient enals straight from aldehydes. This one-step reaction tolerates various functional groups and can be applied to a wide range of substrates giving the products in yields of 52–84%.

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“…The total current is calculated by integration of the current density over the whole electrode surface. For example, for a strip electrode with the length L in the flow direction and width W the Le´veˆque solution applies [11].…”

Section: Methodsmentioning

confidence: 99%