Synthesis of pH-responsive hydrogel based on PVP grafted with crotonic acid for controlled drug delivery

Abstract

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The Use of Poly(N-vinyl pyrrolidone) in the Delivery of Drugs: A Review

“…Up to now, PVP hydrogels were produced by using different methods [124][125][126][127]. However, only a few works were focused on the production of PVP-based hydrogels for drug delivery [5,[26][27][28][29]. For example, PVP K30/pectin hydrogels were prepared by the traditional solution casting technique [26], and then the salicylic acid (the model drug) was incorporated by diffusion method; i.e., the hydrogel is immersed in a solution containing the drug.…”

“…Recently, hydrogels responding to external stimuli, including heat and pH, attracted the attention of many researchers [28,29]. In the case of pH-responsive hydrogels, the drug release is triggered by pH changes, as occurred in the different parts of the human body.…”

“…In the case of pH-responsive hydrogels, the drug release is triggered by pH changes, as occurred in the different parts of the human body. In this context, Ajji et al [28] proposed a PVP hydrogel grafted with crotonic acid, aiming to obtain new pH-responsive systems.…”

“…Being a well-spinnable polymer, PVP fibers loaded with various active ingredients have also been produced [4,[22][23][24][25]. PVP-based hydrogels [5,[26][27][28][29] and oral tablets [27,[30][31][32] have also been proposed in some papers. Furthermore, PVP exhibits an excellent ability to form films [6,[33][34][35][36].…”

Multifunctional Roles of PVP as a Versatile Biomaterial in Solid State

“…PVP hydrogels [22], oral tablets [23], PVP films [24], composite nanoparticles [25], microcapsules [26], and microspheres [27] were also developed. Table 3 [3,22,24,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43] shows a summary of PVP-based drug delivery systems. Gamma irradiation, crosslinking, casting, electrospinning, and grafting were the most used techniques to produce PVP-based hydrogels [22,31,32].…”