Synthesis of s-Triazine-Based Thiazolidinones as Antimicrobial Agents

Abstract

A novel series of thiazolidinone derivatives, namely 4-{4-dimethylamino-6-[4-oxo-2-phenyl-5-(4-pyridin-2-yl-piperazin-1-ylmethyl)-thiazolidin-3-yl]-[1,3,5]-triazin-2-yloxy}-1-methyl-1H-quinolin-2-ones, have been synthesized from the key intermediate 4-(4-amino-6-dimethylamino-[1,3,5]-triazin-2-yloxy)-1-methyl-1H-quinolin-2-one (5). Compound 5 was condensed with various aldehydes to give Schiff base derivatives, which after cyclization gave thiazolidinones that were linked with 1-pyridin-2-yl-piperazine to obtain the target compounds. The newly synthesized compounds were evaluated for their antimicrobial activity against eight bacteria (Staphylococcus aureus, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella typhi, Proteus vulgaris, Shigella fl exneri) and four fungi (Aspergillus niger, Candida albicans, Aspergillus fumigatus, Aspergillus clavatus).

"Experimental Study on Effects of Stabilization of Clayey Soil Using Copper Slag and GGBS "

“…In India, Soil stabilization of the modern era started around the mid-1970 when the shortfall of petroleum and the products happened. 3,4 It was mainly done to improve the soil stability but due to the absence of proper techniques and technologies, it did not flourish. In modern technologies with the high demand for infrastructure all around the world, soil stabilization was revived from the past.…”