Synthesis of some new oxazepine compounds derived from cyanoethyl acetate and study their inhibitory activity against some pathogenic bacterial species

Abstract

Involves synthesis of Schiff bases (hydrazone) by the reaction of acid hydrazide(D1) (which is prepared from the reaction of cyanoethyl acetate with hydrazine hydrate at (85%) with aromatic aldehydes to obtain compounds (D2-6) and by the reaction of compounds (D2-6) with phthalic anhydride Compounds (D7-11) are obtained, the biological activity of the prepared compounds is studied through two types of Gram-positive and Gram-negative bacteria Staph. aureus, Escherichia Coli and Compare it with one type of antibiotic (Gentamycin). The validity of the structures is confirmed by spectroscopic methods (FTIR, 1H-NMR, 13C-NMR, MASS). The disk diffusion assay technique was used to investigate the antibacterial activity in vitro against two types of bacteria: gram-positive and gram harmful bacteria. The minimum inhibitory concentration [MIC] was measured using standard medications. The findings revealed that azetidine derivatives outperformed drugs in inhibiting the growth of both gram-positive and gram-negative bacteria.