Synthesis of substituted pyridine based sulphonamides as an antidiabetic agent

Abstract

This research work describes the synthesis of a new series of heterocyclic compounds, namely sulfonamide derivatives. Sulfonamides are a diverse class of organic compounds having significant and potent biological activities. Diverse synthetic methods have been engaged to build up its various derivatives for different biological functions. In this study, the production of novel pyridine-based heterocyclic compounds having sulfonamide moieties has been elaborated. The obtained sulfonamide-based pyridine scaffold was used to investigate their alpha-amylase inhibition activity. The structures of freshly prepared compounds were described using 1H NMR, 13C NMR, and IR spectroscopic techniques. The molecular docking of sulfonamides performed against porcine pancreatic alpha-amylase using PDB file 1LP was used for generation of grid. All the new synthesized compounds were shown notable anti-diabetic activity.

Design, synthesis, spectral analysis, and biological evaluation of Schiff bases with a 1,3,4-thiadiazole moiety as an effective inhibitor against bacterial and fungal strains

“…Heterocyclic compounds are among the organic substances that have biological activity and are used as medicines in both veterinary and human medicine or as pesticides [1]. Many commercially available drugs contain chemical rings, which could have pharmacological effects or act as a base for pharmacophoric groups to interact with receptors (Figure 1) [2].…”

Research Progress in HIV and Mycobacterium tuberculosis Inhibitors Containing Sulfonamide Moiety

“…Sulphanilamide, the frst sulfonamide antibiotic, was initially synthesized in 1906 and later employed in the late 1930s as an antimicrobial agent [4]. For many years, sulfonamide has been utilized in a broad range of biological activities, including anti-HIV, antifungal, anticancer, antibacterial, antitumor, antituberculosis, antiinfammatory, insecticidal, antidiabetes, and antihepatitis applications [5][6][7][8][9][10][11][12][13]. Tese signifcant functions are attributed to biologically active molecules and their association with fve or six heterocyclicmembered rings linked to the sulfonyl group [14].…”

Nano-Structured Na2CaP2O7: a New and Efficient Catalyst for One-Pot Synthesis of 2-Amino-3-Cyanopyridine Derivatives and Evaluation of Their Antibacterial Activity

“…Indeed, they are key scaffolds in biologically active and naturally occurring substances. Many pharmacological properties of pyridine and its derivatives have been reported including antimicrobial [4], anticancer [5], anti-inflammatory [6], anti-viral [7], anti-diabetic [8], and anti-malarial activities [2]. On the other hand, heterocyclic systems containing the b-enaminonitrile moiety represent a class of intermediates known to be highly reactive and used as precursors for synthesizing newly heterocyclic compounds [9][10][11].…”