Synthesis of superparamagnetic iron oxide nanoparticles coated with a DDNP-carboxyl derivative for in vitro magnetic resonance imaging of Alzheimer's disease

Zhou, Jingting; Fa, Huanbao; Yin, Wei; Zhang, Jin; Hou, Changjun; Huo, Danqun; Zhang, Dong; Zhang, Haifeng

doi:10.1016/j.msec.2014.01.005

Cited by 45 publications

(20 citation statements)

References 42 publications

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“…One significant hurdle in delivering NPs to the central nervous system is the BBB, due to the tight junctions between brain endothelial cells lining brain vascular vessels. NPs including magnetic NPs have been shown to bind Aβ in vitro . However, presumably due to their poor abilities to penetrate into brains, they are not useful for in vivo brain imaging.…”

Section: Discussionmentioning

confidence: 99%

Detection of β‐Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease

Nasr

Kouyoumdjian

Mallett

et al. 2017

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The accumulation and formation of β-amyloid (Aβ) plaques in the brain are distinctive pathological hallmarks of Alzheimer's disease (AD). Designing nanoparticle (NP) contrast agents capable of binding with Aβ highly selectively can potentially facilitate early detection of AD. However, a significant obstacle is the blood brain barrier (BBB), which can preclude the entrance of NPs into the brain for Aβ binding. In this work, bovine serum albumin (BSA) coated NPs are decorated with sialic acid (NP-BSA -Sia) to overcome the challenges in Aβ imaging in vivo. The NP-BSA -Sia is biocompatible with high magnetic relaxivities, suggesting that they are suitable contrast agents for magnetic resonance imaging (MRI). The NP-BSA -Sia binds with Aβ in a sialic acid dependent manner with high selectivities toward Aβ deposited on brains and cross the BBB in an in vitro model. The abilities of these NPs to detect Aβ in vivo in human AD transgenic mice by MRI are evaluated without the need to coinject mannitol to increase BBB permeability. T *-weighted MRI shows that Aβ plaques in mouse brains can be detected as aided by NP-BSA -Sia, which is confirmed by histological analysis. Thus, NP-BSA -Sia is a promising new tool for noninvasive in vivo detection of Aβ plaques.

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Section: Discussionmentioning

confidence: 99%

Detection of β‐Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease

Nasr

Kouyoumdjian

Mallett

et al. 2017

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“…USPIONs chemically coupled with Aß 1–42 were proposed as poorly invasive diagnostic tools for the in vivo detection of amyloid plaques by magnetic resonance microimaging [Yang et al, ]. Due to their increased relaxivity leading to an improvement in the contrast of the image during MRI and in vitro binding to ß‐amiloid aggregates, SPIONs were proposed as ultra‐sensitive nanoprobes for AD imaging [Zhou et al, ]. Several examples of nanovehicles to carry monoclonal antibodies against Aß 1–42 into the brain have been recently developed as theranostic tools, some of them also being able to carry conjugated drugs to the Aß deposits [Poduslo et al, ; Agyare et al, ; Jaruszewski et al, ].…”

Section: Use Of Nms In Diagnosis and Treatment Of Neurodegenerative Dmentioning

confidence: 99%

Nanomaterials and neurodegeneration

Migliore

Uboldi

Bucchianico

et al. 2015

Environ and Mol Mutagen

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The increasing application of nanotechnology in various industrial, environmental, and human settings raises questions surrounding the potential adverse effects induced by nanosized materials to human health, including the possible neurotoxic and neuroinflammatory properties of those substances and their capability to induce neurodegeneration. In this review, a panel of metal oxide nanoparticles (NPs), namely titanium dioxide, silicon dioxide, zinc oxide, copper oxide, iron NPs, and carbon nanotubes have been focused. An overview has been provided of the in vitro and in vivo evidence of adverse effects to the central nervous system. Research indicated that these nanomaterials (NMs) not only reach the brain, but also can cause a certain degree of brain tissue damage, including cytotoxicity, genotoxicity, induction of oxidative stress, and inflammation, all potentially involved in the onset and progression of neurodegeneration. Surface chemistry of the NMs may play an important role in their localization and subsequent effects on the brain of rodents. In addition, NM shape differences may induce varying degrees of neurotoxicity. However, one of the potential biomedical applications of NMs is nanodevices for early diagnostic and novel therapeutic approaches to counteract age related diseases. In this context, engineered NMs were promising vehicles to carry diagnostic and therapeutic compounds across the blood-brain barrier, thereby representing very timely and attractive theranostic tools in neurodegenerative diseases. Therefore, a careful assessment of the risk-benefit ratio must be taken into consideration in using nanosized materials.

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“…The DDNP-SPIONs are prepared by conjugating the DDNP carboxyl derivative to oleic acid-treated SPIONs through ligand exchange. The combination was found to induce the fluorescence enhancement of the DDNP-SPIONs and displayed tremendous promise for use as a contrast agent for MRI of AD (Zhou et al 2014 …”

Section: Surface-modified Nanoparticles In Neurodegenerative Disordersmentioning

confidence: 99%

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

Singh

Kapahi

Rashid

et al. 2015

Artificial Cells, Nanomedicine, and Biotechnology

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Clinically, the therapeutic outcomes in neurodegenerative disorders (NDs) by drug treatment are very limited, and the most insurmountable obstacle in the treatment of NDs is the blood-brain barrier (BBB), which provides the highest level of protection from xenobiotics. A great deal of attention still needs to be paid to overcome these barriers, and surface-engineered polymeric nanoparticles are emerging as innovative tools that are able to interact with the biological system at a molecular level for the desired response. The present review covers the potential importance of surface-structure-engineered nanoparticles to overcome the BBB for good bioavailability, and the evaluation of drug therapy in NDs.

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Synthesis of superparamagnetic iron oxide nanoparticles coated with a DDNP-carboxyl derivative for in vitro magnetic resonance imaging of Alzheimer's disease

Cited by 45 publications

References 42 publications

Detection of β‐Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease

Detection of β‐Amyloid by Sialic Acid Coated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer's Disease

Nanomaterials and neurodegeneration

Recent prospective of surface engineered Nanoparticles in the management of Neurodegenerative disorders

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