Synthesis, oxygen-binding behavior, and Moessbauer spectroscopy of covalently bound polyphosphazene-heme complexes

Allcock, Harry R.; Neenan, Thomas X.; Boso, Brian

doi:10.1021/ic00211a015

Cited by 23 publications

(11 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bioactive molecules that were used in this way included steroids [96] cis-platinum drugs [97], and several antibiotics [98,99]. In addition, the possibility was explored that a water-soluble polyphosphazene could be used as a carrier molecule for heme-type structures, with possible use as an emergency blood substitute [100,101].…”

Section: Polymeric Drugs and Myoglobin Modelsmentioning

confidence: 99%

Expanding Options in Polyphosphazene Biomedical Research

Allcock

2008

Polyphosphazenes for Biomedical Applications

Self Cite

View full text Add to dashboard Cite

Section: Polymeric Drugs and Myoglobin Modelsmentioning

confidence: 99%

Expanding Options in Polyphosphazene Biomedical Research

Allcock

2008

Polyphosphazenes for Biomedical Applications

Self Cite

View full text Add to dashboard Cite

“…Although these were synthesized originally as carriers for iron porphyrins (as hemoglobin/myoglobin models) 76 , 77 they also constitute examples of phosphazene polymers that can be cross-linked by metals.…”

Section: Chartmentioning

confidence: 99%

Crosslinking Reactions for the Conversion of Polyphosphazenes into Useful Materials

Allcock¹

1994

Chem. Mater.

Self Cite

117

View full text Add to dashboard Cite

Approved" "" 27 9 ATION PAGE OMe ,ao0o. 070-08 oaverIae Woiane . io n Cuinw t-e time to, r.w.nq inswuc•t,. s.arcninq existing ol.a source.o.nq t/he cOalt•tnon at informatian. $.no comments ref•ra"nq thim ourcen" estim e or anv other asoe¢t of this n. to Wastinqton m eaaeO udrtws $Seir cui. 0'rectoreie otr t nforvaecion Ooererion i ni o • c rat[s. 1I21 jeffitt le i t ot Manaqement and Suaqet. Pc wor-Wa Redui-tion Protect (0714-0t. 0I.Waeg-ngton, OC 20503. This document has been approved for public release; distribution is unlimited. ABSTRACT (Maximum 200 words)The conversion of phosphazene high polymers to useful materials depends on the development of methods to cross-link the macromolecular chains. A number of cross-linking routes have been used, including chemical, photochemical, and high energy radiation techniques.The relationship of the cross-linking processes to electrochemical-, electrooptical-, elastomer-, structural-, membrane-, surface-, and biomedical properties is discussed. Reproduction in whole or in part is permitted for any purpose of the United States Government. This document has been approved for public release and sale; its distribution is unlimited. 94-16109

show abstract

“…In all experiments, we fixed the amount of acetonitrile and 35 triethylamine at 50 mL and 2 mL, respectively, and adjusted the DBF and HCCP concentrations. Compared to the size of the PCTPDBF NPs in Figure 1, that of NPs decreased to approximately 200 nm (Figure 2a-c The effect of the solvent on precipitation polymerization was also investigated.…”

Section: Resultsmentioning

confidence: 99%

“…Fetal bovine serum (FBS) and high-glucose Dulbecco's modified Eagle's medium (DMEM) were obtained from Hyclone. 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) 35 reagent was purchased from Beyondtime Bio-Tech, China. 4′,6-Diamidino-2-phenylindole dihydrochloride (DAPI, 98%) was purchased from Sigma.…”

Section: Chemicalsmentioning

confidence: 99%

“…Fluorescent proteins represent a type of considerable toolkit with excellent biocompatibility and biospecificity. They have been widely used for studying gene 35 expression, protein transport, and other cellular processes. However, only a small selection of fluorescent proteins is available; in addition, they generally exhibit poor resistance to photobleaching.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

Meng

Liu

et al. 2015

Polym. Chem.

View full text Add to dashboard Cite

5Highly cross-linked and monodisperse polyphosphazene nanoparticles (NPs) exhibiting strong fluorescence were prepared by a remarkably simple one-pot polycondensation of hexachlorocyclotriphosphazene (HCCP) and 4,5-dibromofluorescein (DBF). The morphology and size of the resulting poly(cyclotriphosphazene-co-dibromofluorescein) (PCTPDBF) NPs can be facilely tuned by varying the solvent and reactant concentration. The fluorescent DBF units were isolated and "fastened" in 10 the cross-linked structures, which can well suppress the concentration-quenching effect of small fluorescent probes. Hence, the PCTPDBF NPs emitted bright yellow fluorescence at any concentration. The PCTPDBF NPs could enter HeLa and H9C2 cells and were located in the cytoplasm. Combined with their excellent biocompatibility and improved resistance to photobleaching and protein interference, they can be used as ideal fluorescent agents for cell imaging.

show abstract

Synthesis, oxygen-binding behavior, and Moessbauer spectroscopy of covalently bound polyphosphazene-heme complexes

Cited by 23 publications

References 9 publications

Expanding Options in Polyphosphazene Biomedical Research

Expanding Options in Polyphosphazene Biomedical Research

Crosslinking Reactions for the Conversion of Polyphosphazenes into Useful Materials

One-pot synthesis of highly cross-linked fluorescent polyphosphazene nanoparticles for cell imaging

Contact Info

Product

Resources

About