2017
DOI: 10.1016/j.jinorgbio.2016.12.001
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Synthesis, photophysical properties and structures of organotin-Schiff bases utilizing aromatic amino acid from the chiral pool and evaluation of the biological perspective of a triphenyltin compound

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Cited by 50 publications
(32 citation statements)
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“…Compared with the reference drug, cis ‐platin (4.80±1.11 μmol/l), complexes 3, 4 , and 5 are more active, and 1 and 2 are not, which are similar to those of our previously reported diorganotin analogues . Compounds 3 – 5 belong to the efficient cytostatic agents, but their activities against HeLa are weaker than triphenyltin and tricyclohexyltin analogues . For 1 – 5 , the activity decreased in the order 4 > 3 > 5 > 2 > 1 (R: Cy > n ‐Bu > Ph > Et > Me), indicating that the organotin moiety play an important role in determining cytotoxicity against cancer cells.…”
Section: Resultssupporting
confidence: 80%
“…Compared with the reference drug, cis ‐platin (4.80±1.11 μmol/l), complexes 3, 4 , and 5 are more active, and 1 and 2 are not, which are similar to those of our previously reported diorganotin analogues . Compounds 3 – 5 belong to the efficient cytostatic agents, but their activities against HeLa are weaker than triphenyltin and tricyclohexyltin analogues . For 1 – 5 , the activity decreased in the order 4 > 3 > 5 > 2 > 1 (R: Cy > n ‐Bu > Ph > Et > Me), indicating that the organotin moiety play an important role in determining cytotoxicity against cancer cells.…”
Section: Resultssupporting
confidence: 80%
“…In spite of exhibiting interesting luminescent properties, bioimaging studies of organotin(IV) complexes have been scarcely reported . However, very recently, fluorescence imaging was successfully employed to investigate cytotoxicity of organotin(IV) compounds . Interestingly, Sn(IV) is attached to phenyl (Ph), n ‐butyl ( n ‐Bu) or methyl (Me) groups in these complexes.…”
Section: Introductionmentioning
confidence: 99%
“…The presence of an imine moiety (‐C=N‐) in the ligand skeleton can greatly influence the biological properties of the metal compounds…”
Section: Synthesis Structure and Anti‐cancer Activity Of Triphenymentioning
confidence: 99%
“…Compound 23 was synthesized by reacting Ph 3 SnCl with the sodium salt of 2‐(( E )‐(( Z )‐4‐hydroxypent‐3‐en‐2‐ylidene) amino)‐3‐(1H‐indol‐3‐yl)propanoate, H 2 NaL 11 (Table , entry 5 and Scheme ) in anhydrous chloroform The compound was designed in order to incorporate, in the same ligand skeleton, imino, carboxylate and indole groups, as well as methyl and hydroxide substituents, which are features, together with the phenyl residues coordinated to the tin(IV) cation, that were considered as adequate for the compound acting as inhibitor for tryptophan 2,3‐dioxygenase. The solid‐state structure of 23 was authenticated by single‐crystal X‐ray diffraction, which revealed its 1D polymeric nature, similar to what was described for 17–22 (see above) The monodentate binding mode of carboxylate in 23 was clearly supported by the value (204 cm –1 ) of the difference (Δ) between the asymmetric and the symmetric vibration modes of the carboxylate group [Δ = ν as(OCO) – ν s(OCO) ] in the IR spectrum.…”
Section: Synthesis Structure and Anti‐cancer Activity Of Triphenymentioning
confidence: 99%