Synthesis, Physical Characterization and Biological Activity of Some Schiff Base Complexes

Abstract

Structural modification of organic molecule has considerable biological relevance. Further, coordination of a biomolecules to the metal ions significantly alters the effectiveness of the biomolecules. In view of the antimicrobial activity ligand [bis-(2-aminobenzaldehyde)] malonoyl dihydrazone], metal complexes with Cu(II), Ni(II), Zn(II) and oxovanadium(IV) have been synthesized and found to be potential antimicrobial agents. An attempt is also made to correlate the biological activities with geometry of the complexes. The complexes have been characterized by elemental analysis, molar conductance, spectra and cyclicvoltammetric measurements. The structural assessment of the complexes has been carried out based on electronic, infrared and molar conductivity values.

Synthesis, Characterization, and Biological Activity ofN′-[(Z)-(3-Methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)(phenyl)methyl]benzohydrazide and Its Co(II), Ni(II), and Cu(II) Complexes

“…These strong vibrational bands (cm −1 ) were observed at 1645 and 1596, respectively. The v (C=O) band assigned to the hydrazide moiety shifted to lower frequencies in the metal complexes, suggesting that the carbonyl oxygen was involved in coordination to the metal ions [36–38]. Bands in the region of 1566–1570 cm −1 have been assigned to imino v (C=N) in all the metal complexes.…”

Schiff bases: An emerging potent class of pharmaceuticals

“…The rapid development of these ligands resulted in an enhanced research activity in the field of coordination chemistry leading to very interesting conclusions. Many biologically important schiff bases have been reported in the literature possessing, antibacterial (Biyala et al, 2007;Morad et al 2007;Rajavel et al 2008;Chohan et al, 2007) , antifungal (Rajendran et al, 2002), antimicrobial (Mishra et al, 2008), anticonvulsant (Sridhar et al, 2002), anti HIV , anti-inflammatory ) and antitumor activities (Desai et al, 2001;Ren et al, 2002) Schiff bases derived from a large number of carbonyl compounds and amines are an important class of ligands that coordinate to metal ions via azomethine nitrogen and have been studied extensively (Tumer et al, 1998). Schiff base complexes derived from 4-hydroxysalicylaldehyde and amines have strong anticancer activity e.g.…”

Synthesis and medicinal use of Metal complexes of Schiff Bases

“…The complexes obtained is washed with alcohol and dried. In 2008, Rajavel et al [11] prepared metal complexes of bis(2-aminobenzaldehyde) malonylhydrazone by refluxing the mixture for 3 hrs in alcoholic medium.…”