Synthesis, Physical Properties and Preliminary Investigation of Hemocompatibility of Polyurethanes from Aliphatic Resources with Castor Oil Participation

Abstract

The synthesis of polyurethanes (PURs) from oligoetherdiol, two low molecular diols, castor oil and 4,4'-Methylenebis(cyclohexylisocyanate) is described. These polymers are characterized by measurements of the mechanical bulk and surface properties, preliminary investigation of compatibility with human blood and calcification in static conditions. The critical surface energy of synthesized PURs is similar to the critical surface energy of natural surfaces. Material-induced hemolysis and the changes of platelet counts in blood samples after contact with PURs are very low. Static seven-weeks-calcification testing in a synthetic calcification fluid did not indicate calcification by optical density measurements and by visual inspection and computer image processing of the X-ray films for PURs with and without castor oil.

Modified polycarbonate urethane: Synthesis, properties and biological investigation in vitro

“…Thus, we expected that this monomer, containing long chains of oleic acid, would produce polyurethanes with greater affinity to albumins and antithrombogenic properties. Our investigation of such modified PEUs showed that the material induced low hemolysis and low changes in the level of the morphotic elements in blood 12. Seven weeks of in vitro static calcification testing did not result in calcification of the PEU containing castor oil 12…”

“…The PEU polymer obtained in our previous work12 from polytetramethylene oxide glycol ( M n = 2000) and characterized by a similar hard segment concentration from HMDI, 1,4‐BD and 1,5‐PD, and a similar content of castor oil as PCU‐I, showed a lower σ 100% (6.3–7.2 MPa) and σ b (24.7–26.3 MPa). It also had greater ε b (545%) than PCU‐I.…”

“…In previous work, we described the PEU synthesized from polytetramethylene oxide glycol, cycloaliphatic diisocyanate, low molecular diols, and the triglyceride of the 12‐hydroxyoleic acid (the main ingredient of castor oil) 12. In natural living cells, albumins are bound in complexes with fatty acids.…”

DGBM Tagung

“…Another approach may be seen in nanostructured surfaces to avoid any blood cell or plasma protein adhesion [12,13]. New biomaterials, biohydrid structures, combinations of synthetic and biological polymers such as polysialic acid [Assmann U, Schuster R, Szentivaniy A, Glasmacher B: Electrospinning of polysialic acid and its blends for tissue engineering scaffolds, 2007] will also be demonstrated [8][9][10].…”

Synthesis, Chemical Structure and Properties of Crosslinked Poly(esterurethanes) Based on Unsaturated Oligo(alkyleneester)diols

“…Unsaturated polyurethanes (uPUR), containing double bonds from polyesters soft segments [1][2][3], chain extenders [4,5] or pendant groups [6][7][8][9][10][11][12], belong to a new class of elastomers. Their importance in macromolecular chemistry follows from their possible applicability in syntheses of cross-linked polymers.…”