Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

Ansari, Khursheed; Lal, Chhagan

doi:10.1016/j.ejmech.2009.04.037

Cited by 245 publications

(138 citation statements)

References 31 publications

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“…Attempts to synthesis pyrazolo [3,4-d]-pyrimidine (23) by the reaction of (9) with DMF-DMA failed and only the amid ines (22) were formed wh ich did not cyclize to generate the corresponding (23). All analys is of compounds (21,22,24) are consistent with the proposed structures. The site selectivity in cycloaddition of some nitrogen amb ident nucleophiles with enaminonitrile (6) was also investigate, Thus, reaction of (6) with thiourea in reflu xing ethanol containing catalytic amount of piperid ine afforded a single product for which five isomeric cycloadducts (27), (29),(31),(33) and (35) seemed possible.…”

Section: Chemistrysupporting

confidence: 61%

“…It was interesting to synthesis hybrids possessing biological and pharmacological activit ies due to benzimidazo le [16][17][18][19][20][21][22][23][24][25][26][27][28][29] and certain substituted pyrazoles [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] hoping that this combination may possess a potential analgesic activity along with possible anticancer effect.…”

Section: Introductionmentioning

confidence: 99%

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Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-A]Pyrimidine and Pyrido[2,3-D]Pyrimidine Derivatives

Khalil¹,

Sayed²,

Raslan³

2012

AJOC

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A simple route for the synthesis of 5-aminopyrazole derivatives (9) was described through the readily accessible acrylamide derivative (7). Reaction of the aminopyrazole with different reagents such as ,-unsaturated nitriles affo rded pyrazol[1,5-a]pyrimid ine (13,15,18). The structure of the enaminonitrile (6) was studied with different reagents such as thiourea and 2-thio xo-(1H)-pyrimid ine-4-one (36) afforded pyrimid inethione derivative (35) and the pyrido[2,3-d]pyrimidi ne derivative (41), respectively.

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Section: Chemistrysupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-A]Pyrimidine and Pyrido[2,3-D]Pyrimidine Derivatives

Khalil¹,

Sayed²,

Raslan³

2012

AJOC

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“…Imidazole ring is an important pharmacophore in drug discovery. Extensive biochemical and pharmacological studies have confirmed that imidazole molecule is associated with a wide range of biological activities including anticancer [8,9], antibacterial [10], antifungal [11], antioxidant [12], antihypertensive [13] and anticoagulant [14], properties. In recent years, there have been important applications of azo dye was permeate into the field of electronic industry as a strong components in the DVD-R (digital versatile disc-recordable) because of its characteristic as stable metal azo dyes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral, Thermal and Biological Studies of Some Metal Complexes Derived from Heterocyclic Mono Azo Dye Ligand 2'[(2'-Hydroxy-4-methyl phenyl)azo]imidazole

Al-Adilee¹,

Atyha²

2018

Asian J. Chem.

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Asian Journal of Chemistry; Vol. 30, No. 2 (2018), 280-292 in the azo dyes compounds, such as hydroxyl, carboxylic acid, halogens, esters and amines [19,20]. An important uses of azo imidazole compounds used analytical reagents for solvent extraction to determination of some metal ions [21,22]. The heterocyclic azo imidazole compounds have important role in spectral determination field to determine the trace amount of elements especially transition metal ions and heavy metals because of high sensitivity and selectivity [23,24].The present work describes the synthesis and spectral characterizations of 2'[2'-(1-hydroxy-4-methyl phenyl)azo]-imidazole (HMePAI = HL), containing phenolic-OH function and imidazole moiety. The heterocyclic mono azo dye ligand and its metal complexes were studied by various spectral analysis and screened for their biological activities. As well as the study of ligand and Ni(II) complex of prescription drug anticancer by using the lines of cancerous liver cells of the type HePG2 and compared with line of the ordinary cells.

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“…2 Therefore it was thought that preparing Mannich base derivatives from 2-substituted benzimidazoles would probably result in compounds of having high biological activities toward many diseases. The extensively used as drugs such as proton pump inhibitor 3 (Omeprazole), Antihelmenthetics 4 (Albendazole), antidopaminergic 5 (Domperidone), specifically, the 2-substituted analogs of benzimidazoles are known to be potent biologically active compounds against inflammation, viral and microbial infection. Furthermore, benzimidazole derivatives are structural isosteres of naturally occurring nucleotides, which allows them to interact easily with the biopolymers of the living systems.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterisation and evaluation of N-mannich bases of 2-substituted Benzimidazole derivatives

Kumar¹,

Subramanian²,

Chinnaiyan³

2013

Journal of Young Pharmacists

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a b s t r a c tRationale: Benzimidazoles and its derivatives represent one of the mainly biological active classes of literature. Aim: In this present study aimed to synthesize N-mannich bases derivatives compounds bearing of 2-substituted benzimidazole moiety, in order to investigate their possible biological activity. Method: Benzimidazole compounds were prepared from the condensation reaction between ortho phenylene diamine and various acids. Mannich base of newly synthesized Benzimidazole derivatives were synthesized from 2-substituted Benzimidazoles by reacting with secondary amines. The purity of the compounds was ascertained by melting point (m.p) and thin layer chromatography (TLC). Structures of the synthesized compounds were elucidated by spectral data. Antimicrobial assay was performed by microbroth dilution method. Bacterial genomic DNA cleavage was assessed by Agarose gel electrophoresis. Toxicity of the most effective compounds was studied by Brine-shrimp lethality assay. Result: Among the synthesized compounds, compound 5E (a) and (b) was establish to be the most potent against all tested microorganisms. This two compounds exhibited complete bacterial DNA cleavage and non-toxic. Conclusion: These results suggest that it an interesting compound compared to the current therapeutic agents and are considered to investigate further for the same.

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Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

Cited by 245 publications

References 31 publications

Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-A]Pyrimidine and Pyrido[2,3-D]Pyrimidine Derivatives

Heterocyclic Synthesis Via Enaminonitriles: One-Pot Synthesis of Some New Pyrazole, Pyrimidine, Pyrazolo[1,5-A]Pyrimidine and Pyrido[2,3-D]Pyrimidine Derivatives

Synthesis, Spectral, Thermal and Biological Studies of Some Metal Complexes Derived from Heterocyclic Mono Azo Dye Ligand 2'[(2'-Hydroxy-4-methyl phenyl)azo]imidazole

Synthesis, characterisation and evaluation of N-mannich bases of 2-substituted Benzimidazole derivatives

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