Synthesis, physicochemical, structural and rheological characterizations of carboxymethyl xanthan derivatives

Yahoum, Madiha Melha; Moulai‐Mostefa, Nadji; Cerf, Didier Le

doi:10.1016/j.carbpol.2016.06.080

Cited by 63 publications

(42 citation statements)

References 36 publications

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“…Molecular weights were calculated using the Mark-Howink relationship (Eq. (4)) of intrinsic viscosity to the molar mass of the biopolymer.η=K∗Mawhere K and a are the characteristic constants of the polymer-solvent pair at a given temperature, and their values are generally limited with K = 2.79 10 3 cm 3 /g and a = 1.2754 at 25 °C (Tinland and Rinaudo, 1989, Yahoum et al, 2016).…”

Section: Methodsmentioning

confidence: 99%

Synthesis, characterization and evaluation of deacetylated xanthan derivatives as new excipients in the formulation of chitosan-based polyelectrolytes for the sustained release of tramadol

Boudoukhani

Yahoum

Lefnaoui

et al. 2019

Saudi Pharmaceutical Journal

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This paper addressed the application of deacetylated xanthan (XGDS) and chitosan (CTS) as a mixture blend forming hydrophilic matrices for Tramadol (TD) sustained release tablets. XGDSs derivatives were obtained by alkaline treatment of xanthan gum (XG) with various degrees of deacetylation (DD). The obtained products were characterized in terms of structural, thermal and physicochemical properties. Different tablet formulations containing CTS/XGDSs were prepared by direct compression method and compared to CTS/XG tablets. Flow properties of powder mixtures and pharmaceutical characteristics were evaluated. The dissolution test of TD was realized under simulated gastric and intestinal conditions to achieve drug release more than 24 h. All developed tablets were found conforming to standard evaluation tests. It was shown that CTS/XGDSs matrices ensure a slower release of TD in comparison with CTS/XG based formulations. Meanwhile, increasing DD resulted in a decrease of drug release. In addition, TD release from XGDS matrices was faster at pH (6.8) than at acidic pH (1.2). The matrix tablets based on CTS/XGDS4 (DD = 98.08%) were selected as the best candidates compared to the other systems in prolonging drug release. The optimal formulation was found to release 99.99% of TD after 24 h following a non-Fickian type.

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Section: Methodsmentioning

confidence: 99%

Synthesis, characterization and evaluation of deacetylated xanthan derivatives as new excipients in the formulation of chitosan-based polyelectrolytes for the sustained release of tramadol

Boudoukhani

Yahoum

Lefnaoui

et al. 2019

Saudi Pharmaceutical Journal

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“…Moreover, the gum like other polymers tends to produce “fish‐eye” formation during hydration process (Su, Ji, Lan, & Dong, ). Some physical and chemical modifications of XG have been reported to prevent and eliminate the “fish‐eye” formation of polysaccharides (Smith et al, ; Yahoum, Moulai‐Mostefa, & Le Cerf, ).…”

Section: Introductionmentioning

confidence: 99%

Microencapsulation of xanthan gum based on palm stearin/beeswax matrix as wall system

Ding

Pan

et al. 2019

J Food Process Engineering

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Xanthan gum microcapsules (XGMC) were prepared by phase separation method based on palm stearin/beeswax (PS/BW) systems. XG microcapsules with high encapsulation efficiency were obtained at the preparation conditions of PS-to-BW ratio 7:3 and core-to-wall ratio 10:10. The inverted micrograph showed that the shapes of XGMC were mainly spherical, and the particle sizes of XGMC were chiefly distributed in the range from 40 to 300 μm. The XGMC curve of differential scanning calorimetry (DSC) illustrated that two peaks appeared at around 40 and 60 C, and the two temperatures were in accordance with the melting points of PS and BW, respectively. Compared with that of XG, the hygroscopicity of XG in microcapsules was obviously decreased under medium and high humidity conditions. Viscosity measurements showed that XGMC could be destructed and XG was completely released from microcapsules at temperature above 65 C. The XG released from microcapsules could more fast hydrate than XG, and "fish-eye" would not be formed. Microencapsulation could be an effective method to protect XG from high hygroscopicity, to promote the polysaccharide hydration process, and to prevent the "fish-eye" formation. Practical ApplicationsXG as a hydrophilic polysaccharide is able to strongly absorb moisture and form agglomerates during storage. Moreover, the gum tends to produce "fish-eye" formation during hydration process. These shortcomings are not propitious for XG applications in the food processing industry. Microencapsulation is usually employed to improve the physicochemical properties of active ingredients. XG was encapsulated into palm stearin/beeswax matrix using phase separation method. The hygroscopicity of XG was reduced significantly after microencapsulation, and the "fish-eye" formation was also effectively prevented. The hydration rate and efficiency of XG after microencapsulation were obviously enhanced. The XG microcapsules obtained in this work will promote the application in food industry and increase the economic value of XG. In addition, the system of palm stearin/beeswax could be adequately developed as effective wall materials.

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“…The OBC of E‐RIDF was the highest among the samples, which might be due to the honeycomb structure, the particle size reduction and increased surface areas of E‐RIDF. The etherification between hydroxyl groups of the cellulose and hemicellulose in C‐RIDF might relate to the improvement of the OBC (Yahoum, Moulai‐Mostefa, & Le Cerf, 2016).…”

Section: Resultsmentioning

confidence: 99%

Physicochemical, functional, and antioxidant properties of dietary fiber from Rosa roxburghii Tratt fruit modified by physical, chemical, and biological enzyme treatments

Wang

Shen

Chao

et al. 2020

J. Food Process. Preserv.

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Increased consumption of animal-based food and decreased consumption of cereals and rhizome food have been significant features of the changes in the modern eating habits over the past 20 years, which had numerous negative effects on physical health. Dietary fibers (DFs) are a group of macromolecular carbohydrate extracted from grains, beans, and vegetables, which can be classified into soluble dietary fiber (SDF) and insoluble dietary fiber (IDF) according to their water solubility. Many studies have found that eating a fiber-rich diet can increase the volume of feces, accelerate the speed of defecation, and play a role in preventing constipation (Patel, 2015). Therefore, the beneficial effect of DF on human health has been further investigated with great accomplishments. DF from plant sources (cereals, nuts, fruits, and vegetables) is not directly applied to food products due to its negative impact on food quality, such as taste and appearance (Robin, Schuchmann, & Palzer, 2012). However, some commonly used modification

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Synthesis, physicochemical, structural and rheological characterizations of carboxymethyl xanthan derivatives

Cited by 63 publications

References 36 publications

Synthesis, characterization and evaluation of deacetylated xanthan derivatives as new excipients in the formulation of chitosan-based polyelectrolytes for the sustained release of tramadol

Synthesis, characterization and evaluation of deacetylated xanthan derivatives as new excipients in the formulation of chitosan-based polyelectrolytes for the sustained release of tramadol

Microencapsulation of xanthan gum based on palm stearin/beeswax matrix as wall system

Physicochemical, functional, and antioxidant properties of dietary fiber from Rosa roxburghii Tratt fruit modified by physical, chemical, and biological enzyme treatments

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