Synthesis, psychotropic and anticancer activity of 2,2‐dimethyl‐5‐[5′‐trialkylgermyl(silyl)‐2′‐hetarylidene]‐1,3‐dioxane‐4,6‐diones and their analogues

Abstract

A series of 2,2-dimethyl-5-(5 -R-hetarylidene)-1,3-dioxane-4,6-diones has been synthesized for examing a structure-activity relationship. Furyl and thienyl derivatives of Meldrum's acid possess neurotropic activity comprising both depriming and activating components. Comparison of acute toxicity of carbon, silicon and germanium analogues in the furan series of the compounds has demonstrated that the germanium derivative is 11.5 times less toxic than the carbon analogue and four times less toxic than the silicon derivative. 2,2-Dimethyl-5-(5 -triethylsilyl-2 -thenylidene)-1,3-dioxane-4,6-dione has moderate toxicity with the highest neurotropic and cytotoxic activity

Antifungal, anti-inflammatory and cytotoxicity activities of three varieties of labisia pumila benth: from microwave obtained extracts

“…alata , pumila and lanceolata . These compounds have been reported to have antibacterial and antifungal [25], antioxidant [26] and anticancer activities [27]. It is also known that high concentration of certain fatty acids can cause cell death via apoptosis or necrosis [28].…”

Polyethylene Glycol-400-Functionalized Dicationic Acidic Ionic Liquids for Highly Efficient Conversion of Fructose into 5-Hydroxymethylfurfural

“…These data show that the ketose is more easily dehydrated to HMF than aldose using current conditions. When glucose and cellobiose were subjected to our reaction system, the HMF yield was remarkably inferior (Table 6, entries [10][11][12][13]. This result clearly indicates that PEG 400 -DAILs as Brønsted acid catalysts can hardly promote the isomerization of glucose to fructose.…”

“…In this respect, biomass, which is affluent, pollution-free and widespread, provides an ideal substitute to fossil resources for the production of fine chemicals and fuels [1][2][3][4]. Recently, an increasing efforts have been devoted towards transforming biomass into 5-hydroxymethylfurfural (HMF), which is one of vitally important versatile intermediates for preparing a broad of valuable chemicals [5][6][7][8][9][10][11], polymers [12], pharmaceutical [13].…”

Synthesis, structure and biological activity of new 6,6‐dimethyl‐2‐oxo‐4‐{2‐[5‐organylsilyl(germyl)]furan(thiophen)‐2‐yl}vinyl‐5,6‐dihydro‐2H‐pyran‐3‐carbonitriles

“…Silicon‐ and germanium‐containing heterocyclic aldehydes were regioselectively prepared using a one‐pot procedure . Carbon‐containing heterocyclic aldehydes were synthesized according to a published method .…”