Synthesis, Some Transformations, and Biological Properties of 3-Phenethyl-2-Thioxo-2,3-Dihydro-1H-spiro[Benzo[H]Quinazoline-5,1′-Cycloheptane]-4(6H)-Ones

Condensation of 2-thioxo-2,3-dihydro-1 H -spiro[benzo[ h ]quinazoline-5,1′-cycloheptane]-4(6 H )-one with hydrazine hydrate afforded 2-hydrazinyl-3 H -spiro[benzo[ h ]quinazoline-5,1′-cycloheptane]-4(6 H )-one. The reaction of the latter with orthoformic acid ethyl ester or carbon disulfide yielded 5 H -spiro[benzo[ h ][1,2,4]triazolo[3,4- b ]quinazoline-6,1′-cycloheptane]-7(11 H )-one and 9-mercapto-5 H -spiro[benzo[ h ][1,2,4]triazolo[3,4- b ] quinazoline-6,1 ‘-cycloheptane]-7(11 H )-one, respectively. Alkylation of the latter with methyl and ethyl iodides, allyl bromide, and benzyl chloride gave 9-sulfanyl-substituted 5 H -spiro[benzo[ h ][1,2,4]triazolo[3,4- b ]quinazoline-6,1′-cycloheptane]-7(11 H )-ones. The synthesized compounds exhibited antibacterial properties.

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Synthesis, Some Transformations, and Biological Properties of 3-Phenethyl-2-Thioxo-2,3-Dihydro-1H-spiro[Benzo[H]Quinazoline-5,1′-Cycloheptane]-4(6H)-Ones

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Synthesis, Some Transformations, and Antibacterial Activity of 5H-Spiro[benzo[h][1,2,4]triazolo[3,4-b]quinazoline-6,1′-cycloheptane]-7(11H)-ones

Synthesis, Some Transformations, and Antibacterial Activity of 5H-Spiro[benzo[h][1,2,4]triazolo[3,4-b]quinazoline-6,1′-cycloheptane]-7(11H)-ones

Synthesis, some transformations and antibacterial activity of 5<i>H</i>-spiro[benzo[<i>h</i>][1,2,4]triazolo[3,4-<i>b</i>]quinazoline6,1′-cycloheptane]-7(11<i>H</i>)-ones

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