Synthesis, Spectral Analysis and Anticancer Evaluation of Novel Pyrazoline Derivatives

Abstract

The novel Pyrazoline derivatives were prepared by cyclisation of substituted chalcone derivatives in the presence of 2, 4 dintro phenyl hydrazine hydrate. Structural elucidation of all synthesized derivatives were done by spectral analysis ( IR , NMR and Mass spectroscopy). All synthesized derivatives screened for their anticancer activities by MTT assay and these prepared derivatives exhibits promising anticancer activities.

Synthesis, Molecular Docking, and ADMET Study of N1-Hydrogen and N1-Benzoyl Pyrazoline as Antibacterial Agents

“…The synthesis of pyrazoline compound involves Fischer and Knoevenagel reaction as cyclizations reaction between hydrazine (Hoz et al, 2021) or phenylhydrazine (Jadhav et al, 2018) and chalcone. The 2'-hydroxy chalcone is one of the chalcone derivatives with outstanding activity as an antibacterial agent (Freitas et al, 2020).…”

Design, Synthesis, and Anti-mycobacterial Evaluation of New 3,5-Disubstituted-pyrazole-1-carbothioamides

“…In particular, electron-rich nitrogen heterocycles play a vital role in various pharmacological activities [10]. Pyrazoline was first discovered by Knorr in the year 1883 [11][12]. Pyrazolines are dihydropyrazole, heterocycles having an endocyclic double bond with two adjacent nitrogen atoms at positions 1-and 2-within the five-membered ring, are the most studied group of compounds in the azole family [13].…”

Comparison of various synthesis methods and synthesis parameters of pyrazoline derivates

“…Pyrazoline derivate synthesis is carried out in two stages. In Stage 1, Claisen-Schmidt condensation[ 1 ] was conducted between acetophenone and aromatic aldehyde analogs called the aldol condensation reaction[ 2 ] to get the desired enone. In Step 2, enones are reacted to give the desired pyrazoline by a regioselective synthesis of 1,3,5-triarylpyrazolines.…”

“…[ 8 ] The existence of this structure is very important in pharmacological chemical drugs because the pyrazole ring structure has an active part that can provide many different biological activities. Pyrazoline derivatives have broad biological activity properties that are used effectively[ 9 ] as anti-inflammatory,[ 10 ] antimalarial,[ 1 11 ] antidepressant,[ 12 ] antimicrobial,[ 11 13 ] antileukemic,[ 14 ] antioxidant,[ 15 ] analgesic,[ 16 ] anticancer,[ 2 17 18 ] immunosuppressant,[ 19 ] antidiabetic,[ 20 ] cytotoxic,[ 21 22 ] antihepatotoxic,[ 23 ] and antitumor agents. [ 19 ]…”