Synthesis, spectral characterization, and antidiabetic study of new furan-based vanadium(IV) complexes

Sheela, Angappan; Vijayaraghavan, R.

doi:10.1080/00958972.2010.550916

Cited by 16 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complexation by organic ligands is one of the effective ways to improve the vanadium efficacy and decrease the toxic side effects. The potential applications of vanadium complexes as molecular magnets and in material science are well documented [7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Vanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach

Sharma

Das

Sadhu

et al. 2022

Journal of Coordination Chemistry

View full text Add to dashboard Cite

The oxidovanadium(IV) complex [VO(HL) 2 ] (1) (where, HL = 4-nitrocinnamohydroxamate; 4-NO 2 C 6 H 4 CH=CHCONHOH) has been synthesized by the condensation reaction of VOSO 4 •5H 2 O and potassium 4-nitrocinnamohydroxamate in methanol-water medium. The complex is characterized by elemental analysis, molar conductivity, magnetic susceptibility measurement, FTIR, UV-Vis, Electron Paramagnetic Resonance (EPR) spectral techniques and mass spectrometry. The bidentate linkage of hydroxamate ligand involving O,O-coordination through hydroxamic and carbonyl oxygen atoms has been deduced. The magnetic susceptibility, EPR and mass spectra (ESI-MS) indicate that the complex exists as monomer and a distorted square pyramidal geometry around vanadium is proposed. The electrochemical study of 1 has shown it is to be electrochemically active exhibiting VO V /VO IV quasi-reversible redox couple. The thermal study of the complex yielded VO 2 as sole decomposition product. The coordination compounds 2 and 3 have been isolated from the reaction of complex 1 with 2-cyanopyridine (2-CNPy) and 4-aminobenzonitrile (4-CNAn) respectively and characterized by physicochemical and IR spectral study. The biological activity of 1-3 has been studied against various pathogenic bacteria E. coli, S. aureus, S. typhi, S. paratyphi, S. epidermidis, K. pneumonia and fungi C. albicans, B. fulva, and F. oxysporum by minimum inhibitory concentration (MIC) method. The complexes exhibit enhanced antimicrobial activity relative to both the free ligand and vanadyl sulphate. The cytotoxicity of 1-3 has been studied on mammalian transformed cell line Hep2c, a derivative of human cervix carcinoma HeLa cells by MTT assay. 2 and 3 exhibit higher cytotoxic activity than 1 and reveal a marked effect of the coordination of nitrogen bases.Density functional theory studies have been carried out to determine the relative free energy of formation and stable molecular structures of 1-3. Time dependent density functional theory (TD-DFT) based calculation have been performed to find out the frontier molecular orbitals and to corroborate with the experimentally observed UV-Vis spectrum of 1. Other parameters like HOMO, and LUMO energies, density of state (DOS), and global reactivity descriptors clearly support higher biological activity of 2 and 3 than 1.

show abstract

Section: Introductionmentioning

confidence: 99%

Vanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach

Sharma

Das

Sadhu

et al. 2022

Journal of Coordination Chemistry

View full text Add to dashboard Cite

show abstract

Selective Formation of 2,3,5‐Trisubstituted Furans from 1,3‐Dicarbonyls and Hydroxyketones

Yan,

Shou,

Qin

et al. 2023

Adv Synth Catal

View full text Add to dashboard Cite

Chemoselective cyclizations of 1,3‐dicarbonyl compounds with hydroxyketones for the selective formation of two 2,3,5‐trisubstituted furans have been reported. While TsOH‐mediated cyclization in DCM afforded 2‐acylfurans, the additional copper catalyst in acetone turned over the selectivity for the generation of 3‐acylfurans. The featured advantages of both reactions include simple conditions, high yielding, broad substrate scope, gram scalability, and H2O as the sole byproduct.

show abstract

A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes

2012

View full text Add to dashboard Cite

Synthesis, spectral characterization, and antidiabetic study of new furan-based vanadium(IV) complexes

Cited by 16 publications

References 54 publications

Vanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach

Vanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach

Selective Formation of 2,3,5‐Trisubstituted Furans from 1,3‐Dicarbonyls and Hydroxyketones

A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes

Contact Info

Product

Resources

About