Synthesis, spectral characterization and DNA bindings of tridentate N 2 O donor Schiff base metal(II) complexes

Kathiresan, Sellamuthu; Anand, Thangavel; Mugesh, Subramanian; Annaraj, Jamespandi

doi:10.1016/j.jphotobiol.2015.04.016

Cited by 30 publications

(7 citation statements)

References 46 publications

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“…The complete rupture of the cells depicted that the complex bound to the cell wall and ruptured it due to oxidative stress on E. coli, entering into the nucleus, thereby degrading the chromosomal DNA by preventing protein synthesis which is essential for all cellular metabolism. 109 With the specific goal of assessing the impact of metal atoms upon chelation, some biologically active SB ligands obtained from 5-chloro-3-phenyl-1H-indole-2-carboxyhydrazide and 3-formyl-2-hydroxy-1H-quinoline and their CuĲII), CoĲII), NiĲII), ZnĲII), CdĲII), and HgĲII) complexes were thoroughly studied and characterized by various sophisticated spectral studies ( Fig. 11).…”

Section: Antimicrobial Activity Of Hsb Transition Metal Complexesmentioning

confidence: 99%

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

et al. 2018

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In recent years, the number of people suffering from cancer and multidrug-resistant infections has sharply increased, leaving humanity without any choice but to search for new treatment options and strategies. Although cancer is considered the leading cause of death worldwide, it also paves the way many microbial infections and thus increases this burden manifold. Development of small molecules as anticancer and anti-microbial agents has great potential and a plethora of drugs are already available to combat these diseases. However, the wide occurrence of multidrug resistance in both cancer and microbial infections necessitates the development of new and potential molecules with desired properties that could circumvent the multidrug resistance problem. A successful strategy in anticancer chemotherapy has been the use of metallo-drugs and this strategy has the potential to be used for treating multidrug-resistant infections more efficiently. As a class of molecules, Schiff bases have been the topic of considerable interest, owing to their versatile metal chelating properties, inherent biological activities and flexibility to modify the structure to fine-tune it for a particular biological application. Schiff base-based metallo-drugs are being researched to develop new anticancer and anti-microbial chemotherapies and because both anticancer and anti-microbial targets are different, heterocyclic Schiff bases can be structurally modified to achieve the desired molecule, targeting a particular disease. In this review, we collect the most recent and relevant literature concerning the synthesis of heterocyclic Schiff base metal complexes as anticancer and anti-microbial agents and discuss the potential and future of this class of metallo-drugs as either anticancer or anti-microbial agents.

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Section: Antimicrobial Activity Of Hsb Transition Metal Complexesmentioning

confidence: 99%

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

et al. 2018

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“…Upon progressive addition of ct‐DNA (0.00–4.0 × 10 −5 M) to fixed concentration of complexes (0.2 × 10 −4 M), a hyperchromic effect with a slightly blue shift of 3 to 5 nm was observed for the LMCT band centred at 407 nm (Figure ). The observed hyperchromism could be attributed to the external contact (surface binding) of complexes with ct‐DNA duplex via electrostatic mode, further synergised by other non‐covalent hydrogen‐bonding interactions of COO − and ─NH 2 of l ‐/ d ‐phenylalanine and 4‐(2‐aminoethyl)benzenesulfonamide, respectively. Additionally, hyperchromism with blue shift was also observed around 275 nm suggestive of stabilization of DNA double‐helix structure.…”

Section: Resultsmentioning

confidence: 99%

Spectroscopic and single‐crystal X‐ray diffraction studies of enantiomeric copper(II) Schiff base one‐dimensional coordination polymers with 4‐(2‐aminoethyl)benzenesulfonamide appendage: Comprehensive biological evaluation (DNA binding, cleavage, superoxide dismutase mimetic activity, topoisomerase I inhibition and cytotoxicity)

Afsan

Roisnel

Tabassum

et al. 2019

Applied Organom Chemis

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New chiral Cu(II)‐based one‐dimensional coordination polymers [l‐C25H27CuN3O6S] (1a) and [d‐C25H27CuN3O6S] (1b) were designed and synthesized by in situ reaction of Schiff base (o‐vanillin and l‐/d‐phenylalanine) and appended ligand 4‐(2‐aminoethyl)benzenesulfonamide incorporated with Cu(II) ion. The enantiomeric complexes 1a and 1b were fully characterized using various spectroscopic techniques and single‐crystal X‐ray diffraction studies. The enantiomeric analogues 1a and 1b crystallized in chiral monoclinic P21 space group with z = 2 exhibiting a distorted square pyramidal environment around Cu(II) metal centre coordinated to N2O3 donor atoms with apical position occupied by adjacent bridging carboxylate oxygen, resulting in one‐dimensional polymeric chain structures. Comprehensive biological studies of 1a and 1b (DNA binding, superoxide dismutase (SOD), topoisomerase I and cytotoxic activity) were performed which revealed that 1a showed better prospects as a therapeutic drug candidate as compared to 1b as quantified by their comparative DNA binding (Kb, K and Ksv values), SOD mimetic activity (IC50 values of 0.160 and 0.198, respectively) and anticancer properties.

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“…These Ni(II) complexes are diamagnetic in nature. The complexes 3 and 6 displayed broad band at 588 nm and 671 nm respectively, attributed to 2 B 1g → 2 E g for Cu(II) complexes [22,23]. The magnetic moment values of 3 is 1.81 BM and 6 is 1.75 BM.…”

Section: Ft-ir Spectramentioning

confidence: 95%

Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases

Ramesh

Kumar

Rambabu

et al. 2018

AJOCS

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A series of [Co(L I ) 2 ] (1), [Ni(L I ) 2 ] (2), [Cu(L I ) 2 ] (3), [Co(L II ) 2 ] (4), [Ni(L II ) 2 ] (5) and [Cu(L II ) 2 ] (6) complexes where L I = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-5-methoxyphenol and L II = 2-((E)-(5-(4-fluorophenyl)isoxazol-3-ylimino)methyl)-4-bromophenol, were synthesized and characterized by elemental analysis, Infrared, UV-visible, Nuclear magnetic resonance, Mass spectral studies, Electron Spin Resonance, Thermogravimetric analysis, Magnetic moment, Scanning Electron Microscope and Powder X-ray Diffraction analyses. From the analytical results, all these metal (II) complexes are assigned to square planar geometry around the metal ions. The DNA-binding and cleavage studies were evaluated for the synthesized compounds with CT-DNA and supercoiled pBR322 DNA, respectively. All compounds have been monitored for their in Vitro antimicrobial assay.

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Synthesis, spectral characterization and DNA bindings of tridentate N 2 O donor Schiff base metal(II) complexes

Cited by 30 publications

References 46 publications

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

Heterocyclic Schiff base transition metal complexes in antimicrobial and anticancer chemotherapy

Synthesis, Spectral Characterization, DNA Binding, Cleavage and Biological Evaluation on Co(II), Ni(II) and Cu(II) Complexes of Substituted Isoxazole Schiff Bases

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