Synthesis, spectral characterization, crystal and molecular structure studies of 5-(5‑bromo‑2-thienyl)-1-(phenyl)-3-phenyl-2-pyrazoline

Naveen, S.; Ahmad, Noor Aisyah; Urs, M.V. Deepa; Gowda, N. S. Linge; Jamalis, Joazaizulfazli; Reddy, Kakarla Raghava; Lokanath, N.K.

doi:10.1016/j.cdc.2018.08.008

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…It has been reported that the introduction of the acetyl group at first position enhances the molluscicidal activity as well as increases the stability of pyrazolines (Mishriky et al, 1996). Moreover, pyrazolines are extensively useful synthons in organic chemistry and also, they have played a crucial role in the development of theory in heterocyclic chemistry (Ahmad et al, 2016;Shivalingegowda et al, 2017;Naveen et al, 2018;Sathish et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

X-Ray Powder Diffraction Data for a New Pirazoline Compound

Delgado¹,

Delgado-Niño²,

Lobatón³

et al. 2019

PTQ

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Pyrazolines are important agents in medicinal chemistry as a promising scaffold for structural modification and drug development studies due to their wide range of biological activities such as anticancer, antifungal, antibacterial, antidepressant, anticonvulsant, antitubercular, antioxidant, antileishmanial and antiinflammatory activity. These heterocyclic compounds can be prepared by refluxing chalcone with hydrazine hydrate and anhydrous sodium acetate in the presence of glacial acetic acid. The structural characterization, molecular and crystalline structure, of these organic compounds, allows studying their biological properties to know their potential applications. Hence the use of XRPD is very important because it allows obtaining a record to be used as a method of identification. The aim of this investigation was to obtain and reported good quality Xray powder diffraction data the pyrazoline compound 1-(3-(4-iodophenyl)-5-(3-methyl thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethan-1-one, which could be used as potential anti-microbial and anti-cancer agent. The powder pattern was indexed in the monoclinic space group I2/a with unit cell parameters a = 25.440(5) Å, b = 5.124(2) Å, c = 26.261(6) Å, b = 105.75(2)° and figures of merit M20= 38.2 and F20= 66.6 (0.00573, 53). All measured lines were indexed and are consistent with the monoclinic space group. The powder pattern will be included in the Powder Diffraction File database to be used as a reference.

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