Synthesis, spectroscopic analysis (FT-IR, UV and NMR) and DFT analysis of novel prodrugs of pregnane, their apoptotic activity in cervical cancer cell lines

Sethi, Arun; Singh, Ranvijay Pratap; Yadav, Neera; Banerjee, Monisha

doi:10.1016/j.molstruc.2018.04.009

Cited by 8 publications

(3 citation statements)

References 18 publications

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“…16α-Amino-pregnenolone derivatives showed cytotoxicity against HeLa cells. 6 Other effects of such compounds involved anti-dyslipidemic and anti-oxidant activities, 7 enzyme inhibition towards DPP-IV, an enzyme associated with immune regulation, signal transduction and apoptosis, 8 and an inhibitory effect on C17,20-lyase. 9 In the latter case, the 16α-imidazolyl derivative was found to be the most potent inhibitor.…”

Section: Introductionmentioning

confidence: 99%

Catalyst- and excess reagent recycling in aza-Michael additions

Maksó,

Szele,

Ispán

et al. 2024

Org. Biomol. Chem.

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Section: Introductionmentioning

confidence: 99%

Catalyst- and excess reagent recycling in aza-Michael additions

Maksó,

Szele,

Ispán

et al. 2024

Org. Biomol. Chem.

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“…[ 1 ] Previously a number of synthetic pregnenolone derivatives have shown high cytotoxic activity toward cancer cell lines (PC‐3, prostatic adenocarcinoma; MCF‐7, mammary adenocarcinoma; and SKLU‐1, lung adenocarcinoma) and one noncancerous cell line (HGF, human gingival fibroblast). [ 2 ] Pregnenolone derivatives also possess anticancer activity against lung cancer, [ 3 ] cervical cancer, [ 4,5 ] and breast cancer. [ 6,7 ]…”

Section: Introductionmentioning

confidence: 99%

“…[1] Previously a number of synthetic pregnenolone derivatives have shown high cytotoxic activity toward cancer cell lines (PC-3, prostatic adenocarcinoma; MCF-7, mammary adenocarcinoma; and SKLU-1, lung adenocarcinoma) and one noncancerous cell line (HGF, human gingival fibroblast). [2] Pregnenolone derivatives also possess anticancer activity against lung cancer, [3] cervical cancer, [4,5] and breast cancer. [6,7] In continuation of our research toward synthesis of new drug that is effective against lung cancer, novel pregnenolone derivatives were synthesized with the help of Heck and Steglich reaction.…”

Section: Introductionmentioning

confidence: 99%

Pregnenolone derivatives as potential anti‐lung cancer agents: A combined in silico and in vitro approach

Sethi

Yadav

Singh

et al. 2022

J Chinese Chemical Soc

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Synthesis of C‐3 and C‐20 pregnenolone derivatives using Steglich and Heck reaction has been reported. The structures of compounds were established by 1H, 13C NMR, NOESY, FT‐IR, and ESI‐MS. The anticancer activity against lung cancer proficiency assessment was performed using the prediction of activity spectra for substances (PASS) technique and the results were compared with the FDA‐approved lung cancer drug dacomitinib. Molecular docking studies were carried out to investigate the inhibitory action of steroidal derivatives against the lung cancer cell protein (2ITO). The result of the docking exhibited a significant inhibitory action against the lung cancer protein (2ITO) and the binding energy (ΔG) values of 2, 3, 4, 5, 6, 7, 8, 9, 10, and 11 against the protein 2ITO were found to be −10.1, −10.8, −9.2, −9.4, −10.1, −9.4, −11.0, −10.9, −9.7, and −9.5 Kcal/mol, respectively. In vitro lung cancer activity analyses of these compounds against lung cancer cell line (A549) showed that compounds 2 and 3 were more potent than other compounds. Results of in silico and in vitro analysis revealed that they showed good correlation. Drugs likeness and ADMET analysis of all derivatives have also been studied.

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Synthesis of 2-hydroxyethyl dibutyldithiocarbamate and its adsorption mechanism on chalcopyrite

Huang

Wang

et al. 2019

Applied Surface Science

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Synthesis, spectroscopic analysis (FT-IR, UV and NMR) and DFT analysis of novel prodrugs of pregnane, their apoptotic activity in cervical cancer cell lines

Cited by 8 publications

References 18 publications

Catalyst- and excess reagent recycling in aza-Michael additions

Catalyst- and excess reagent recycling in aza-Michael additions

Pregnenolone derivatives as potential anti‐lung cancer agents: A combined in silico and in vitro approach

Synthesis of 2-hydroxyethyl dibutyldithiocarbamate and its adsorption mechanism on chalcopyrite

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