Synthesis, spectroscopic characterization and catalytic activity of platinum(II) carbene complexes

Abstract

A novel platinum complex with 1,3-bis(2,6-diisopropylphenyl)-1,3-dihydro-2H-imidazol-2-ylidenyl ligand has been synthesized and characterized on the basis of elemental analysis, MS, 1 H and 13 C NMR spectroscopy, X-ray Absorption Spectroscopy and single crystal X-ray diffraction studies. The XRD determination of the complex (monoclinic, C2/c) revealed a structure in which the platinum (II) centre coordinates two chlorides, a carbon atom of the N-heterocyclic carbene (NHC) and is stabilized by coordinating the nitrogen atom of a 3-chloropyridine molecule, forming an overall square planar geometry. By prolonging the time of the reaction, it was possible to obtain the trans-dichloridobis(3-chloropyridine) platinum(II) complex under the same reaction conditions. The electronic and molecular properties of both complexes were investigated and compared by means of Near Edge X-ray Absorption Fine Structure spectroscopy (NEXAFS), supported by numerical simulations. The platinum carbene complex obtained was tested in a series of C-H activation and hydrosilylation reactions.

Synthesis, Structural Characterization and Anti‐Proliferative Activity of (κ1‐C)‐ and (κ2‐C,S)‐PtII Complexes Bearing Thioether‐Functionalized N‐Heterocyclic Carbenes

“…The carbene–platinum and platinum–pyridine bond lengths of 1.985(10) and 2.6041(8) Å, respectively, are both in accordance with the literature. [18d], [18f], [18g], [18h], [18k], [18l], [18m], [18n], The two iodide ligands adopt a trans geometry (I–Pt–I angle of 177.30°) and lie almost perpendicular to the plane of the NHC ligand a classical feature that has been observed in such complexes. [18d], [18f], [18g], [18h], [18k], [18l], [18m], [18n], …”

Characterization of new Pt(IV)–thiazole complexes: Analytical, spectral, molecular modeling and molecular docking studies and applications in two opposing pathways

“…This may be attributed to crosslinking of DNA strands by metal complexes via coordination of nucleic acid bases, which then encourages apoptosis of cancer cells . Also, platinum‐based complexes are significant catalysts for cycloisomerization, hydrosilylation and selective hydrolysis of peptides containing either histidine or methionine residues . Platinum‐based antitumor drugs are associated with serious side effects (loss of balance, swelling of feet or lower legs, ringing in ears, trouble in hearing) and drug impedance in the therapeutic process .…”

“…[4] Also, platinum-based complexes are significant catalysts for cycloisomerization, hydrosilylation and selective hydrolysis of peptides containing either histidine or methionine residues. [5][6][7] Platinum-based antitumor drugs are associated with serious side effects (loss of balance, swelling of feet or lower legs, ringing in ears, trouble in hearing) and drug impedance in the therapeutic process. [8] This has prompted chemistry and pharmaceutical researchers to design and synthesize more effective, less toxic metalbased anticancer drugs.…”

Three Reactions, One Catalyst: A Multi‐Purpose Platinum(IV) Complex and its Silica‐Supported Homologue for Environmentally Friendly Processes

“…Monodisperse subnanometer Pt clusters of controlled size have been prepared and tested as catalysts in hydrogenation of styrene, while Pt NPs stabilized with polyphenols were found efficient in biphasic hydrogenation of a series of unsaturated compounds . Pt(II) complexes were also studied as catalysts in hydrosilylation of styrene and as improved alternative for curing of silicone rubber by hydrosilylation . A neutral Pt(II) complex in its supramolecular assembly (microcrystalline fibbers) has been studied as a highly efficient polarized yellow‐orange light emitter .…”