Synthesis, spectroscopic characterization, antimicrobial, antitubercular and DNA cleavage studies of 2-(1H-indol-3-yldiazenyl)-4, 5, 6, 7-tetrahydro-1, 3-benzothiazole and its metal complexes

Synthesis, Characterization and Biological Studies on 3d-Metal Complexes of 5-[(1, 5-Dimethyl-3-oxo-2-Phenyl-2, 3-Dihydro-1H-Pyrazol-4-yl) Diazenyl]-1-Ethyl-6-Hydroxy-4-Methyl-2-oxo-1, 2-Dihydropyridine-3-Carbonitrile

“…we have synthesized a ligand derived from 4-amino antipyrine by simple diazo-coupling method in an acidic medium at lower temperature. It is a simple, convenient and economical method of electrophilic substitution reaction between an aromatic amine with a strong nucleophile in acidic medium at 0-5 o C as described in earlier reports [25][26][27][28][29][30][31]. An accurately weighed 0.002 mol solution of 4-aminoantipyrine (1) in dilute HCl was added to the cold solution of the NaNO 2 in 2 mL H 2 SO 4 with constant stirring at 0-5 o C for 2 h. Then, the formed diazonium salt solution was slowly added to the previously cooled solution of a coupling component ethylpyridone (2) (0.002 mol) in 5 mL aqueous KOH and stirred for another 2 h at the same temperature.…”

Crystal Structure of a Bis[1-(benzothiazole-2yl-2<i>κN</i>)(2-Pyridylmethyliden-1<i>κN</i>)(hydrazino-2<i>κN)</i>] Cobalt(II) Complex

“…The bond lengths N3-C8 and his related homologue N6-C19 are essentially double bond character with distance of 1.287(15) Å and 1.270(4) Å respectively. The sulfur atom of each ligand remains uncoordinated [31]. In each Lthe two heterocycles show a dihedral angle of 4.09(7)° resulting in quasi-coplanarity of non-hydrogen atoms of the ligand.…”

Synthesis and Antitumor Activity of Novel 4-Aminoquinazoline Derivatives Containing Benzothiazole

“…[21] Benzothiazole is an important benzo five-membered heterocyic ring, which was discovered in 1880. Benzothiazole derivatives have a variety of biological activities, such as deworming, [22] ntiviral, [23][24] analgesia, [25][26] anti-tu-mor, [27][28] anti-bacterial, [29][30] anti-inflammatory, [31][32] antituberculosis [33] and anti-malarial. [34] In 2015, Cai et al [35] reported that compounds 5～7 containing benzothiazole had strong cytotoxic effect against six human cancer cell lines.…”