Synthesis, Spectroscopic Characterization, Crystal structure, Antimicrobial and In Vitro Hemolytic Studies of Some Novel Substituted Thiourea Derivatives

Crystal structures of N-[(4-phenylthiazol-2-yl)carbamothioyl]benzamide and N-{[4-(4-bromophenyl)thiazol-2-yl]carbamothioyl}benzamide from synchrotron X-ray diffraction

“…The bond-length and angle distribution within molecules (I) and (II) are almost identical and in good agreement with those observed in related compounds (Singh et al, 2012(Singh et al, , 2013. The values for the C-S-C angle in (I) [88.06 (8) ] and (II) [87.75 (14) ] are also very close to those in previously reported analogous structures [87.62 (7)-88.11 (8) ] (Yunus et al, 2008;Saeed et al, 2010).…”

In Vitro Anti-Microbial Activity and Anti-Cancer Potential of Novel Synthesized Carbamothioyl-Furan-2-Carboxamide Derivatives

“…The general structure of carbamothioyl-aryl-2-carboxamide is shown in Figure 1. Carbamothioyl-aryl-2-carboxamide derivatives including furane, thiazole, benzothiozole, and thiophene moieties showed active anti-fungal (i), anti-bacterial (ii) and anti-cancer potential (iii) [5,6] (Figure 2). Carbamothioyl-aryl-2-carboxamide derivatives including furane, thiazole, benzothiozole, and thiophene moieties showed active anti-fungal (i), anti-bacterial (ii) and anti-cancer potential (iii) [5,6] (Figure 2).…”

“…Carbamothioyl-aryl-2-carboxamide derivatives including furane, thiazole, benzothiozole, and thiophene moieties showed active anti-fungal (i), anti-bacterial (ii) and anti-cancer potential (iii) [5,6] (Figure 2). Carbamothioyl-aryl-2-carboxamide derivatives including furane, thiazole, benzothiozole, and thiophene moieties showed active anti-fungal (i), anti-bacterial (ii) and anti-cancer potential (iii) [5,6] (Figure 2). Scientists are attempting to incorporate furan-based building blocks into drug molecules to give them exceptional medicinal properties.…”

“…Carbamothioyl-aryl-2-carboxamide derivatives including furane, thiazole, benzothiozole, and thiophene moieties showed active anti-fungal (i), anti-bacterial (ii) and anti-cancer potential (iii) [ 5 , 6 ] ( Figure 2 ).…”

“…Heteroatom-containing compounds are biologically active, and they are building blocks for various drug molecules [ 16 , 17 ]. Due to the presence of heteroatoms (N, S and O) in carbamothioyl-aryl-2-carboxamide, its derivatives have a variety of biological functions and are broadly used in the field of medicinal chemistry [ 5 , 6 ]. ( Figure 2 ).…”