Synthesis, Spectroscopic, Molecular Modelling and Antimicrobial Studies of Fluorine Containing Schiff Base

Abstract

A new bi-dentate ON type of Schiff base ligand obtained by condensation of salicylaldehyde (2-hydroxy-benzaldehyde) and 2-fluoroaniline (1-amino-2-fluorobenzene) have been synthesized. The structure of the ligand was characterized by elemental analysis, infra-red, LC-MS, electronic spectra, 1 H-NMR and powder XRD studies. By using Argus labs molecular modeling studies of the ligand was carried out. The Schiff base ligand was tested for antimicrobial activity against bacterial and fungal strains such as Gram positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungal strains such as Sclerotium rolfsii and Macrophamina phaseolina. The experimental data signifies that the ligand exhibited good biological activity.