Synthesis, spectroscopy (IR, multinuclear NMR, ESI-MS), diffraction, density functional study and in vitro antiproliferative activity of pyrazole-beta-diketone dihalotin(IV) compounds on 5 melanoma cell lines

Synthesis of carbohydrate-conjugate heterobimetallic CuII–Sn2IV and ZnII–Sn2IV complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity

“…It is known that 119 Sn chemical shift d ( 119 Sn) is sensitive towards the coordination sphere around the tin atom. 119 Sn NMR spectra of both 1 and 3 showed a single peak for two tin metal atoms at À585 ppm and À619 ppm, respectively due to the same environment around the tin centers [33,34]. These chemical shift values are in close agreement with the octahedral environment around the tin atoms in the heterobimetallic complexes previously reported by our group [24,25].…”

Antiproliferative and anti-tumor activity of organotin compounds

“…Two 4-acylpyrazolon-5-ato-dihalotin(IV) complexes, [Q 2 SnCl 2 ], (HQ Bn = 1,2-dihydro-3-methyl-1-phenyl-4-(2-phenylacetyl)pyrazol-5-one (136) and HQ CF3,py = (4-(2,2,2-trifluoroacetyl)-1,2-dihydro-3-methyl-1-(pyridin-2-yl)pyrazol-5-one (137) (Scheme 7B), were tested for their in vitro antiproliferative activity against three human melanoma cell lines and two melanoma cell clones [46]. The results showed dose-dependent decrease of cell proliferation in all cell lines for both complexes 136 and 137.…”

Reactivity of Thiosemicarbazides with Redox Active Metal Ions: Controlled Formation of Coordination Complexes versus Heterocyclic Compounds

“…Complexes of thiosemicarbazide or thiosemicarbazone ligands with non-transition metals such as tin have not received much attention and there are few reports in the literature, in spite of the potential applications of tin compounds, for example as anticancer agents, [18][19][20][21] anti-inflammatory drugs, [22] PVC stabilisers [23] and pesticides. [24] The coordination chemistry of tin in solution and in the solid state is an attractive target for structural studies by means of spectroscopic and diffraction techniques, with the advantage of the detecting subtle changes in the coordination sphere of the tin atom with great sensitivity by 119 Sn NMR spectros copy.…”