Synthesis, structural and conformational study of selected N-substituted phthalimides

Abstract

This paper synthesizes N -substituted phthalimides derived from nitrogen heterocycles as potential 5-HT 4 ligands by using the Mitsunobu reaction. Conformational studies of some of the new compounds have been conducted using 1 H and 13 C-NMR spectroscopy. Proton and carbon resonances were achieved through the application of onedimensional selective NOE, two-dimensional NMR techniques -homonuclear COSY-45, NOESY and heteronuclear 1 H-13 C HMQC correlated spectroscopy-and double resonance experiments. The crystal structure of compound 1 was determined by X-ray diffraction.