Synthesis, structural characterization and biological evaluation of novel mixed-ligand Co(II) complexes as quorum sensing inhibitory agent

Hopa, Çiğdem; Kara, Hülya; Aybey, Aynur

doi:10.1016/j.molstruc.2019.127322

Cited by 10 publications

(7 citation statements)

References 60 publications

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“…The scientific literature reports a large diversity of species concerning both metal ions and ligands available for designing such effective anti-biofilm species ranging from simple to bulky ligands and acting as unidentate to multidentate species. A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , <...>…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…A variety of complexes with anti-biofilm activity, ranging from species with known antibiotics or natural products to new synthetic ligands, mainly with low toxicity and chelating ability have been developed [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 ,…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…The most recent data concerning these aspects are presented in this review, with highlights on examples of complexes with antibiotics [ 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], N-heterocycle derivatives [ 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 ], Schiff bases [ 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ], biguanides [ 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , …”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

“…The complex was screened for antibacterial activities against Gram-positive ( B. substilis ) and Gram-negative ( P. aeruginosa , S. typhimurium , Shigella sonnei and Y. enterocolitica ) bacterial strains. The effects of these complexes on QS-regulated behaviours of bacteria such as swarming and biofilm formation were also examined [ 97 ].…”

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

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Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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Microbial biofilms are represented by sessile microbial communities with modified gene expression and phenotype, adhered to a surface and embedded in a matrix of self-produced extracellular polymeric substances (EPS). Microbial biofilms can develop on both prosthetic devices and tissues, generating chronic and persistent infections that cannot be eradicated with classical organic-based antimicrobials, because of their increased tolerance to antimicrobials and the host immune system. Several complexes based mostly on 3D ions have shown promising potential for fighting biofilm-associated infections, due to their large spectrum antimicrobial and anti-biofilm activity. The literature usually reports species containing Mn(II), Ni(II), Co(II), Cu(II) or Zn(II) and a large variety of multidentate ligands with chelating properties such as antibiotics, Schiff bases, biguanides, N-based macrocyclic and fused rings derivatives. This review presents the progress in the development of such species and their anti-biofilm activity, as well as the contribution of biomaterials science to incorporate these complexes in composite platforms for reducing the negative impact of medical biofilms.

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Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

Section: Complexes With Antibiofilm Activitymentioning

confidence: 99%

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Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

2022

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“…4) was proved to be effective against a variety of bacterial strains and could reduce swarming and biofilm formation processes regulated by the quorum sensing (QS) communication system in bacteria. The antibacterial activity of 53 was attributed to the presence of the isoselenocyanate ligands in the Co(II) complex [125].…”

Section: Metal Complexes Based On Pt Pd Cu and Comentioning

confidence: 99%

Metal-based compounds containing selenium: An appealing approach towards novel therapeutic drugs with anticancer and antimicrobial effects

Ramos-Inza

Plano

Sanmartín

2022

European Journal of Medicinal Chemistry

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Perfluoropyridine as an Efficient, Tunable Scaffold for Bis(pyrazol‐1‐yl)pyridine Copper Complexes

et al. 2020

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This report details the syntheses of five new 2,6bis(pyrazol-1-yl)pyridine ligands carried out by a unique strategy of utilizing pentafluoropyridine for the pyridine core. Formation of each ligand is accomplished under mild conditions utilizing carbonate bases. Each ligand reacts readily with copper(II) triflate to form the corresponding salt in high yield. Ligands and complexes were characterized by a combination of multi-nuclear NMR, FTIR, UV/Vis, and single-crystal X-ray diffrac- [a] Scheme 1. Synthetic strategies for bis(pyrazol-1-yl)pyridine ligands.

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Synthesis, structural characterization and biological evaluation of novel mixed-ligand Co(II) complexes as quorum sensing inhibitory agent

Cited by 10 publications

References 60 publications

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Metal Complexes—A Promising Approach to Target Biofilm Associated Infections

Metal-based compounds containing selenium: An appealing approach towards novel therapeutic drugs with anticancer and antimicrobial effects

Perfluoropyridine as an Efficient, Tunable Scaffold for Bis(pyrazol‐1‐yl)pyridine Copper Complexes

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